Journal ArticleDOI
Relationship between CHOP/GADD153 and unstable human carotid atherosclerotic plaque
TLDR
The role of CHOP/GADD153 in unstable atherosclerotic plaque formation isolated from confounding factors such as diabetes mellitus, primary hyperlipidemia, autoimmune deficiencies/abnormalities, essential hypertension, chronic heart failure, chronic kidney disease, and smoking is clarified.Abstract:
Background and aims: The signaling protein C/EBP homologous protein (CHOP) and corresponding growth-arrest-and-DNA-damage-inducible gene 153 (GADD153) is associated with endoplasmic reticulum stress (ERS), which can lead to apoptosis Our study aims to elucidate the role of CHOP/GADD153 in unstable atherosclerotic (AS) plaque formation isolated from confounding factors such as diabetes mellitus, primary hyperlipidemia, autoimmune deficiencies/abnormalities, essential hypertension, chronic heart failure, chronic kidney disease, and smokingMaterial and methods: We collected carotid artery tissue samples from patients aged 50–80 years-old who received carotid endarterectomies (CEA) at our institution We obtained fresh AS plaque samples during CEA and preserved the specimens immediately in the operating room with liquid nitrogen Samples were categorized as stable or unstable AS plaques according to a six-stage histologic classification CHOP/GADD153 expression was then examined with immunohistochemread more
Citations
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Journal ArticleDOI
Effect of endoplasmic reticulum stress-induced apoptosis in the role of periodontitis on vascular calcification in a rat model.
TL;DR: In this article, the authors investigated the mechanism through which endoplasmic reticulum stress (ERS)-induced apoptosis, in the role of periodontitis, affects vascular calcification.
Journal ArticleDOI
Salidroside inhibits the proliferation and migration of gastric carcinoma cells and tumor growth via the activation of ERS-dependent autophagy and apoptosis
TL;DR: The present work provides a comprehensive effective evaluation of Salid for treating gastric cancer and the detailed investigation of the underlying mechanisms may offer a rational reference for the future applications ofSalid in clinic.
Journal ArticleDOI
CHOP Increases TRIB3-Dependent miR-208 Expression to Potentiate Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating TIMP3 in Atherosclerosis
Rui Chen,Yan Zhang,Chunyan Zhao +2 more
TL;DR: In this paper, the role and underlying mechanism of CHOP in atherosclerosis were defined and a mouse model of the disease was established by high-fat feeding, where miR-208 expression was determined.
Posted ContentDOI
The Function Role of Ubiquitin Proteasome Pathway in the ER Stress-induced AECII Apoptosis during Hyperoxia Exposure
TL;DR: The findings indicate that UPP may participate in the ERS-induced AECII apoptosis under hyperoxia condition, and the relatively up-regulated in the levels of total ubiquitinated proteins expression and 20S proteasome activity were correlated with increased ERS sensors expression.
Journal ArticleDOI
Contribution of Endoplasmic Reticulum Stress to the Clinical Instability of Carotid Plaques in Human Carotid Stenosis
Kohkichi Hosoda,Taichiro Imahori,Kazuhiro Tanaka,Takiko Uno,Tomoaki Nakai,Masaaki Kohta,Atsushi Fujita,Takashi Sasayama +7 more
TL;DR: In this article, the authors investigated the association between endoplasmic reticulum (ER) stress and clinical instability of carotid plaque and found that the coexpression of the ER stress markers exhibited a significant correlation with clinical instability.
References
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A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
H. C. Stary,A. B. Chandler,R. E. Dinsmore,Valentin Fuster,S. Glagov,William Insull,M. E. Rosenfeld,C. J. Schwartz,W. D. Wagner,R. W. Wissler +9 more
TL;DR: The histological classification of human atherosclerotic lesions found in the second part of this report led to the earlier definitions of precursor lesions, and the appearance of lesions noted in clinical imaging studies with histological lesion types and corresponding clinical syndromes was attempted.
Journal ArticleDOI
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
H. C. Stary,A. B. Chandler,S. Glagov,John R. Guyton,W Insull,M. E. Rosenfeld,S A Schaffer,C. J. Schwartz,W. D. Wagner,R. W. Wissler +9 more
TL;DR: The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed.
Journal ArticleDOI
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
H. C. Stary,A. B. Chandler,S. Glagov,John R. Guyton,W Insull,M. E. Rosenfeld,S A Schaffer,C. J. Schwartz,W. D. Wagner,R. W. Wissler +9 more
TL;DR: The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed.
Journal ArticleDOI
Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum
TL;DR: The cellular responses to the accumulation of unfolded proteins in the ER are much more extensive than previously recognized and will provide new insights into not only fundamental principles in cell biology but also the pathogenesis of diseases that result from problems in protein folding in theER.
Journal ArticleDOI
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
Bo Feng,Pin Mei Yao,Yankun Li,Cecilia Devlin,Dajun Zhang,Heather P. Harding,Michele Sweeney,James X. Rong,George Kuriakose,Edward A. Fisher,Andrew R. Marks,David Ron,Ira Tabas +12 more
TL;DR: It is proposed that cholesterol trafficking to endoplasmic reticulum membranes, resulting in activation of the CHOP arm of the UPR, is the key signalling step in cholesterol-induced apoptosis in macrophages.