Journal ArticleDOI
Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid.
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TLDR
The finding that ingestion of niacin evokes the release of markedly increased quantities ofPGD2 in vivo in humans suggests that PGD2 is the mediator of niakin-induced vasodilation in humans.About:
This article is published in Prostaglandins.The article was published on 1989-08-01. It has received 254 citations till now. The article focuses on the topics: Niacin & Laropiprant.read more
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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Tadahiro Shimazu,Matthew D. Hirschey,John C. Newman,Wenjuan He,Kotaro Shirakawa,Natacha Le Moan,Carrie A. Grueter,Hyung W. Lim,Laura Saunders,Robert Stevens,Christopher B. Newgard,Robert V. Farese,Rafael de Cabo,Scott M. Ulrich,Katerina Akassoglou,Eric Verdin +15 more
TL;DR: It is reported that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), and treatment of mice with βOHB conferred substantial protection against oxidative stress.
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International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)
Stefan Offermanns,Steven L. Colletti,Timothy W. Lovenberg,Graeme Semple,Alan Wise,Adriaan P. IJzerman +5 more
TL;DR: The aim of this article is to give an overview on the discovery and pharmacological characterization of HCAs, and to introduce an International Union of Basic and Clinical Pharmacology (IUPHAR)-recommended nomenclature for this receptor family.
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Arachidonic acid cascade and signal transduction.
Takao Shimizu,Leonhard S. Wolfe +1 more
TL;DR: Recent progress of research in this field is summarized with special attention directed to eicosanoid metabolism, functions of eICosanoids in the neuroendocrine system and synaptic transmission, current information on eicOsanoid receptors, and the link between eicOSanoids and cerebral circulation.
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Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review
TL;DR: A basic effect of nicotinic acid is the inhibition of fat‐mobilizing lipolysis in adipose tissue leading to a lowering of plasma free fatty acids, which has many metabolic implications which are reviewed.
Journal ArticleDOI
Mechanism of action of niacin.
TL;DR: Initial data suggest that niacin, by inhibiting the hepatocyte surface expression of beta-chain adenosine triphosphate synthase (a recently reported HDL-apo A-I holoparticle receptor), inhibits the removal of HDL-AP-I.
References
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Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
Paul L. Canner,Kenneth G. Berge,Nanette K. Wenger,Jeremiah Stamler,Lawrence S. Friedman,Ronald J. Prineas,William T. Friedewald +6 more
TL;DR: The Coronary Drug Project was conducted to assess the long-term efficacy and safety of five lipid-influencing drugs in 8,341 men aged 30 to 64 years with electrocardiogram-documented previous myocardial infarction, and niacin treatment showed modest benefit in decreasing definite nonfatal recurrent myocardia but did not decrease total mortality.
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The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
TL;DR: The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study.
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Increased production of prostaglandin D2 in patients with systemic mastocytosis.
TL;DR: It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for mastocytosis evaluation based on prior history and once they provide informed consent for surgery.
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Estimated rate of prostacyclin secretion into the circulation of normal man.
TL;DR: The much lower estimates obtained in this study suggest that endogenous PGI2 is unlikely to act as a circulating antiplatelet agent in healthy man.
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A double blind placebo controlled crossover study of prostacyclin in man.
TL;DR: Prostacyclin sodium was administered in a double blind crossover trial to 6 normal males at infusion rates of 2, 4 and 8 ng/kg/minute but plasma aldosterone and plasma norepinephrine did not change and marked facial flushing occured with PGI 2.