Journal ArticleDOI
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
TLDR
The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study.Abstract:
Both n–3 and n–6 polyunsaturated fats have been suggested to lower blood pressure, an effect ascribed to altered biosynthesis of eicosanoids. To test these hypotheses, we studied blood pressure and eicosanoid production during supplementation of dietary fat for four weeks in 32 men with mild essential hypertension. Supplementation was preceded and followed by four-week run-in and recovery periods. Groups of eight subjects received either 10 ml or 50 ml of fish oil (3 or 15 g of n–3 fatty acids) daily, 50 ml of safflower oil (39 g of n–6 fatty acids), or 50 ml of a mixture of oils that approximated the types of fat present in the American diet. The biosynthesis of eicosanoids was assessed by the measurement of urinary metabolites. Blood pressure decreased in the men who received the high dose of fish oil (systolic pressure by a mean of 6.5 mm Hg [P<0.03] and diastolic pressure by 4.4 mm Hg [P<0.015]), but not in the other groups. Although the formation of vasodilatory prostacyclins (prostaglandins...read more
Citations
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Journal ArticleDOI
Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials.
TL;DR: In this article, the antihypertensive effect of fish oil was estimated from randomized trials using metaregression analysis, and the effect of age, gender, blood pressure, and body mass index was examined.
Journal ArticleDOI
The Effects of Nonpharmacologic Interventions on Blood Pressure of Persons With High Normal Levels: Results of the Trials of Hypertension Prevention, Phase I
Paul K. Whelton,Lawrence J. Appel,Jeanne Charleston,Arlene Taylor Dalcin,Craig K. Ewart,Linda P. Fried,Delores Kaidy,Michael J. Klag,Shiriki K. Kumanyika,Lyn Steffen,W. Gordon Walker,Albert Oberman,Karen Counts,Heidi Hataway,James M. Raczynski,Neil Rappaport,Roland Weinsier,Nemat O. Borhani,Edmund Bernauer,Patricia A. Borhani,Carlos de la Cruz,Andrew Ertl,Doug Heustis,Marshall Lee,Wade Lovelace,Ellen O'Connor,Liz Peel,Carolyn Sugars,James O. Taylor,Beth Walker Corkery,Denis A. Evans,Mary Ellen Keough,Martha Clare Morris,Eleanor Pistorino,Frank M. Sacks,Mary Cameron,Sheila Corrigan,Nancy King Wright,William B. Applegate,Amy Brewer,Laretha Goodwin,Stephen T. Miller,Joseph T. Murphy,Judy Randle,Jay M. Sullivan,Norman L. Lasser,David M. Batey,Lee Dolan,Sheila Hamill,Pat Kennedy,Vera I. Lasser,Lewis H. Kuller,Arlene W. Caggiula,N. Carole Milas,Monica E. Yamamoto,Thomas M. Vogt,Merwyn R. Greenlick,Jack F. Hollis,Victor J. Stevens,Jerome D. Cohen,Mildred Mattfeldt-Beman,Connie Brinkmann,Katherine Roth,Lana Shepek,Charles H. Hennekens,Julie E. Buring,Nancy R. Cook,Ellie Danielson,Kim Eberlein,David Gordon,Patricia R. Hebert,Jean MacFadyen,Sherry L. Mayrent,Bernard Rosner,Suzanne Satterfield,Heather Tosteson,Martin Van Denburgh,Jeffrey A. Cutler,Erica Brittain,Marilyn Farrand,Peter G. Kaufmann,Ed Lakatos,Eva Obarzanek,John Belcher,Andrea Dommeyer,Ivan Mills,Peggy Neibling,Margo Woods,B.J. Kremen Goldman,Elaine Blethen +89 more
TL;DR: Weight reduction is the most effective of the strategies tested for reducing blood pressure in normotensive persons, and sodium reduction is also effective.
Journal ArticleDOI
Does fish oil lower blood pressure? A meta-analysis of controlled trials.
TL;DR: There is a dose-response effect of fish oil on blood pressure of -0.66/-035 mm Hg/g wt-3 fatty acids, and the hypotensive effect may be strongest in hypertensive subjects and those with clinical atherosclerotic disease or hypercholesterolemia.
Journal ArticleDOI
Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials
Heather O Dickinson,James Mason,Donald J Nicolson,Fiona Campbell,Fiona Beyer,Julia V Cook,Bryan Williams,Gary A. Ford +7 more
TL;DR: Patients with elevated blood pressure should follow a weight-reducing diet, take regular exercise, and restrict alcohol and salt intake, as available evidence does not support relaxation therapies, calcium, magnesium or potassium supplements to reduce blood pressure.
Journal ArticleDOI
Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases
TL;DR: The marine environment represents a relatively untapped source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification and the prevention of chronic diseases.
References
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Nonparametric statistics for the behavioral sciences
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Journal ArticleDOI
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