Resting heart Rate and the risk of death and cardiovascular complications in patients with type 2 diabetes mellitus
Graham S. Hillis,Mark Woodward,Anthony Rodgers,Clara K Chow,Qiang Li,Sophia Zoungas,Anushka Patel,Ruth Webster,George David Batty,Toshiharu Ninomiya,Giuseppe Mancia,Neil R Poulter,John Chalmers +12 more
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TLDR
Among patients with type 2 diabetes, a higher resting heart rate is associated with an increased risk of death and cardiovascular complications, and it remains unclear whether a higher heart rate directly mediates the increased risk or is a marker for other factors that determine a poor outcome.Abstract:
Aims/hypothesis
An association between resting heart rate and mortality has been described in the general population and in patients with cardiovascular disease. There are, however, few data exploring this relationship in patients with type 2 diabetes mellitus. The current study addresses this issue.read more
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UKPDS Outcomes Model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year United Kingdom Prospective Diabetes Study: UKPDS 82
TL;DR: A new version of the United Kingdom Prospective Diabetes Study Outcomes Model (UKPDS-OM2), a patient-level simulation tool for predicting lifetime health outcomes of people with type 2 diabetes mellitus, is built and predicts event rates for complications, which are lower than those from the existing model.
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Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet
TL;DR: The modulation of autonomic function by SGLT2i represents a promising research field with possible clinical relevance and there is no conclusive evidence for a disease-modifying therapy, treatment of CAN manifestations is available, and efforts to overcome CAN under-diagnosis are on the table.
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Differential effects of glucagon-like peptide-1 receptor agonists on heart rate
Martin Lorenz,Francesca Lawson,David R. Owens,Denis Raccah,Christine Roy-Duval,Anne Lehmann,Riccardo Perfetti,Lawrence Blonde +7 more
TL;DR: Findings from recently completed trials indicate that a GLP-1 RA-induced increase in HR, regardless of magnitude, does not present an increased cardiovascular risk for subjects with T2DM, although a pronounced increase inHR may be associated with adverse clinical outcomes in those with advanced heart failure.
Journal ArticleDOI
Effect of SGLT2 Inhibitors on the Sympathetic Nervous System and Blood Pressure.
TL;DR: The effects of sodium-glucose cotransporter type 2 inhibitors (SGLT2is) on blood pressure and more especially on SNS activity in patients with T2DM are analyzed.
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Evaluating the risk of type 2 diabetes mellitus using artificial neural network: An effective classification approach
Chongjian Wang,Linlin Li,Ling Wang,Zhiguang Ping,Muanda Tsobo Flory,Gaoshuai Wang,Yuan-lin Xi,Wenjie Li +7 more
TL;DR: The ANN model is an effective classification approach for identifying those at high risk of T2DM based on demographic, lifestyle and anthropometric data.
References
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Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
Anushka Patel,Stephen MacMahon,John Chalmers,Bruce Neal,Laurent Billot,Mark Woodward,Mark Woodward,Michel Marre,Mark E. Cooper,Paul Glasziou,Paul Glasziou,Diederick E. Grobbee,Pavel Hamet,Stephen B. Harrap,Simon Heller,Lisheng Liu,Giuseppe Mancia,Carl Erik Mogensen,C. Y. Pan,Neil R Poulter,Anthony Rodgers,Bryan Williams,Severine Bompoint,Bastiaan E. de Galan,Bastiaan E. de Galan,Rohina Joshi,F. Travert +26 more
TL;DR: A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21%relative reduction in nephropathy.
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Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.
Karl Swedberg,Michel Komajda,Michael Böhm,Jeffrey S. Borer,Ian Ford,Ariane Dubost-Brama,Guy Lerebours,Luigi Tavazzi +7 more
TL;DR: In this article, the effect of heart rate reduction by the selective sinus-node inhibitor ivabradine on outcomes in heart failure was evaluated in a randomized, double-blind, placebo-controlled, parallel-group study.
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Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
TL;DR: Routine administration of a fixed combination of perindopril and indapamide to patients with type 2 diabetes was well tolerated and reduced the risks of major vascular events, including death, which suggest that over 5 years, one death due to any cause would be averted.
Journal ArticleDOI
Diabetic Autonomic Neuropathy
TL;DR: There are studies in progress that suggest that autonomic nerves can be induced to regenerate, and the future for patients with diabetic autonomic neuropathy is brighter.
Journal ArticleDOI
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans
TL;DR: This study suggests that acute increases in plasma insulin within the physiological range elevate sympathetic neural outflow but produce forearm vasodilation and do not elevate arterial pressure in normal humans.