Review on uremic toxins: Classification, concentration, and interindividual variability
Raymond Vanholder,Rita De Smet,Griet Glorieux,Àngel Argilés,Ulrich Baurmeister,Philippe Brunet,William R. Clark,Gerald Cohen,Peter Paul De Deyn,Reinhold Deppisch,Béatrice Descamps-Latscha,Thomas Henle,Achim Jörres,Horst Dieter Lemke,Ziad A. Massy,Jutta Passlick-Deetjen,Mariano Rodriguez,Bernd Stegmayr,Peter Stenvinkel,Ciro Tetta,Christoph Wanner,Walter Zidek +21 more
TLDR
Concentrations of retention solutes in uremia vary over a broad range, from nanograms per liter to grams per liter, and a substantial number of molecules are protein bound and/or middle molecules, and many of these exert toxicity and are characterized by a high range of toxic over normal concentration (CU/CN ratio).About:
This article is published in Kidney International.The article was published on 2003-05-01 and is currently open access. It has received 1404 citations till now. The article focuses on the topics: Uremia.read more
Citations
More filters
Journal ArticleDOI
Normal and Pathologic Concentrations of Uremic Toxins
Flore Duranton,Gerald M. Cohen,Rita De Smet,Mariano Rodriguez,Joachim Jankowski,Raymond Vanholder,Àngel Argilés +6 more
TL;DR: A literature search found 621 articles about uremic toxicity published after a 2003 review of this topic and found most solutes (59%) in only one report, which should aid the design of experiments to study the biologic effects of these solutes in CKD.
Journal ArticleDOI
Chronic kidney disease as cause of cardiovascular morbidity and mortality.
TL;DR: It is concluded that there is an undeniable link between kidney dysfunction and cardiovascular risk and that the presence of even subtle kidney dysfunction should be considered as one of the conditions necessitating intensive prevention of this cardiovascular risk.
Journal ArticleDOI
Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease.
Victoria Cachofeiro,Marian Goicochea,Soledad García de Vinuesa,Pilar Oubiña,Vicente Lahera,José Luño +5 more
TL;DR: Statin administration is accompanied by risk reduction in all major vascular events in patients with CKD that are considered high-risk patients, and beneficial effects seem to be consequence of not only their hypolipidemic effect but especially their pleitropic actions that involve modulation of oxidative stress and inflammation.
Journal ArticleDOI
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification.
TL;DR: Recent advances in the understanding of the functional roles of UGT, their regulation and tissue expression, and clinical significant factors (ontogeny, interactions and polymorphisms) that affect glucuronidation activity in humans are discussed.
Journal ArticleDOI
The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate: A Systematic Review
TL;DR: A systematic approach allowed the retrieval of methodologically correct studies unbiased by erroneous conditions related to albumin binding, and the data seem to confirm the toxicity of indoxyl sulfate and p-cresyl sulfates and support their roles in vascular and renal disease progression.
References
More filters
Journal ArticleDOI
Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study
TL;DR: This study concludes that a large percentage of hemodialysis patients who have a serum phosphorus level above 6.5 mg/dL and that this places them at increased risk of death, and supports the need for vigorous control of hyperphosphatemia to improve patient survival.
Journal ArticleDOI
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.
TL;DR: In-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine, ADMA is described, which might contribute to the hypertension and immune dysfunction associated with chronic renal failure.
Journal ArticleDOI
Death Risk in Hemodialysis Patients: The Predictive Value of Commonly Measured Variables and an Evaluation of Death Rate Differences Between Facilities
Edmund G. Lowrie,Nancy L. Lew +1 more
TL;DR: Strategies designed to improve the overall mortality statistic for dialysis patients in the United States would be better directed toward improving the quality of care for all patients, particularly high-risk patients, within their usual treatment settings rather than trying to identify facilities with high death rate for possible regulatory intervention.
Journal ArticleDOI
Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study
Carmine Zoccali,Stefanie M. Bode-Böger,Francesca Mallamaci,F. Benedetto,Giovanni Tripepi,Lorenzo Malatino,Alessandro Cataliotti,Ignazio Bellanuova,Isabella Fermo,Jürgen C. Frölich,Rainer H. Böger +10 more
TL;DR: In haemodialysis patients, plasma ADMA is a strong and independent predictor of overall mortality and cardiovascular outcome, and lends support to the hypothesis that accumulation of AD MA is an important risk factor for cardiovascular disease in chronic renal failure.
Journal ArticleDOI
Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: Recommendations for a change in management
TL;DR: It is shown that the current treatment paradigm for serum phosphorus and secondary hyperparathyroidism is ineffective for a large segment of dialysis patients, and it is believed that prevention of uremic calcification, cardiac death, and vascular disease should assume primary importance when evaluating the risks associated with elevated levels of phosphorus, CaxP, and PTH.
Related Papers (5)
Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis
Garabed Eknoyan,Gerald J. Beck,Alfred K. Cheung,John T. Daugirdas,Tom Greene,John W. Kusek,Michael Allon,James L. Bailey,James A. Delmez,Thomas A. Depner,Johanna T. Dwyer,Andrew S. Levey,Nathan W. Levin,Edgar L. Milford,Daniel B. Ornt,Michael V. Rocco,Gerald Schulman,Steve J. Schwab,Brendan P. Teehan,Robert D. Toto +19 more