Journal ArticleDOI
Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents.
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TLDR
A method for the pyridine-directed, rhodium-catalyzed, site-selective C-H alkylation and arylation of pyridones using commercially available trifluoroborate reagents with perfect site selectivity is developed.About:
This article is published in Organic Letters.The article was published on 2016-10-13. It has received 61 citations till now. The article focuses on the topics: Alkylation.read more
Citations
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A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.
Carlo Sambiagio,David Schönbauer,Remi Blieck,Toan Dao-Huy,Gerit Pototschnig,Patricia Schaaf,Thomas Wiesinger,Muhammad Farooq Zia,Joanna Wencel-Delord,Tatiana Besset,Bert U. W. Maes,Michael Schnürch +11 more
TL;DR: The present review is devoted to summarizing the recent advances (2015–2017) in the field of metal-catalysed group-directed C–H functionalisation.
Journal ArticleDOI
Sulfoxonium Ylides as a Carbene Precursor in Rh(III)-Catalyzed C–H Acylmethylation of Arenes
TL;DR: The sulfoxonium ylides system proceeded under redox-neutral conditions with a broad scope, high efficiency, and functional group tolerance.
Journal ArticleDOI
A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls
Koji Hirano,Masahiro Miura +1 more
TL;DR: This minireview focuses on recent advances in site-selective C–H functionalization on 2-pyridone which is an important heterocyclic motif in medicinal and pharmaceutical chemistry.
Journal ArticleDOI
Installing the "magic methyl"- C-H methylation in synthesis.
Daniya Aynetdinova,Mia C Callens,Harry B Hicks,Charmaine Y X Poh,Benjamin D A Shennan,Alistair M Boyd,Zhong Hui Lim,Jamie A. Leitch,Darren J. Dixon +8 more
TL;DR: In this paper, a review of the diverse techniques that have been employed to enable the selective installation of the C-Me bond in a wide range of chemical structures, from simple building blocks to complex drug-like architectures.
Journal ArticleDOI
Rhodium(III)-Catalyzed C6-Selective Arylation of 2-Pyridones and Related Heterocycles Using Quinone Diazides: Syntheses of Heteroarylated Phenols.
TL;DR: An efficient, direct C6-arylation of 2-pyridones has been successfully accomplished with quinone diazides under Rh(III)-catalyzed redox-neutral conditions and provides a facile access to complex heteroarylated phenol moieties by wide-ranging heterocyclic scaffolds.
References
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Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
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Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
TL;DR: A review of palladium-catalyzed coupling of CH bonds with organometallic reagents through a PdII/Pd0 catalytic cycle can be found in this paper.
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Transition-metal-catalyzed direct arylation of (hetero)arenes by C-H bond cleavage.
TL;DR: P palladium and ruthenium catalysts have been described that enable the direct arylation of (hetero)arenes with challenging coupling partners--including electrophilic aryl chlorides and tosylates as well as simple arenes in cross-dehydrogenative arylations.
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Towards mild metal-catalyzed C–H bond activation
TL;DR: This critical review summarizes and discusses endeavours towards the development of mild C-H activation methods and wishes to trigger more research towards this goal.
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C–C, C–O and C–N bond formation via rhodium(III)-catalyzed oxidative C–H activation
Guoyong Song,Fen Wang,Xingwei Li +2 more
TL;DR: The facile construction of C-E (E = C, N, S, or O) bonds makes Rh(III) catalysis an attractive step-economic approach to value-added molecules from readily available starting materials.