Journal ArticleDOI
Role and regulation of the fibroblast growth factor axis in human thyroid follicular cells.
Helen C. Cocks,Stuart D. Thompson,Frances E. Turner,Ann Logan,Jayne A. Franklyn,John Watkinson,Margaret C. Eggo +6 more
TLDR
It is concluded that TSH stimulates FGFR1 but not FGF-2 expression, and TSH synergizes with PKC activators, which may contribute to goitrogenesis.Abstract:
Thyroidal levels of fibroblast growth factor-2 (FGF-2) and fibroblast growth factor receptor 1 (FGFR1) are elevated in human thyroid hyperplasia. To understand the significance of this, effects of ...read more
Citations
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Choanal Atresia and Choanal Stenosis
TL;DR: The merits of stents, lasers, CT-guided surgery, and the use of additional agents including mitomycin C are reviewed, as well as the particular problems associated with managing bilateral choanal atresia in neonates.
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Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements
TL;DR: Broad applicability of this approach was demonstrated by similar targeting of the ISS elements of the human hnRNPA1 gene, which showed the ability to manipulate endogenously expressed mRNA variants under normal and diseased physiological states.
Journal ArticleDOI
Relevance of iodine intake as a reputed predisposing factor for thyroid cancer
TL;DR: Iodine is a trace element that is essential for the synthesis of thyroid hormone and is associated with thyroid cancer risk, particularly in women as discussed by the authors, but no clear relationship between overall thyroid cancer incidence and iodine intake was found.
Journal ArticleDOI
Current Updates on Choanal Atresia
TL;DR: This review provides a comprehensive clinical update on CA and identifies areas for future study based on the existing available literature.
Journal Article
The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity.
TL;DR: The modification of an environmental factor, ie dietary iodine, over the last 40 years in Greece has been associated with changes in the phenotypic expression of thyroid disease from endemic goiter to goiter associated with autoimmune thyroiditis.
References
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Journal ArticleDOI
Fibroblast growth factors, their receptors and signaling.
TL;DR: FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.
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Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
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Culture of hormone-dependent functional epithelial cells from rat thyroids
TL;DR: It is shown that maintenance in vitro of these specialized functions of rat thyroid follicular cells is dependent on low serum concentrations and supplementation with hormones in the primary cultures and may be aplicable to the general problem of maintenance of differentiated characteristics in cultures of other epithelial cells.
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Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
TL;DR: It is suggested that Spry functions in a negative feedback mechanism in which its inhibitor activity is controlled rapidly and reversibly by post-translational mechanisms.
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Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis.
TL;DR: It is reported here that pituitary pttg is regulated in vivo and in vitro by estrogen and proposed a previously unknown paracrine growth factor-mediated mechanism for pituitsary tumor pathogenesis and potentially other estrogen-regulated tumors.