Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?
James C. Iatridis,Steven B. Nicoll,Arthur J. Michalek,Benjamin A. Walter,Benjamin A. Walter,Michelle S. Gupta +5 more
TLDR
The role of biomechanics on disc degeneration and regenerative therapies is evaluated with a focus on what biomechanical properties need to be repaired and how to evaluate and accomplish such repairs using biomaterials.About:Â
This article is published in The Spine Journal.The article was published on 2013-03-01 and is currently open access. It has received 250 citations till now.read more
Citations
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Mechanics and biology in intervertebral disc degeneration: a vicious circle
Pieter-Paul A. Vergroesen,Idsart Kingma,Kaj S. Emanuel,Roel J. W. Hoogendoorn,Tim J. M. Welting,B.J. van Royen,J.H. van Dieen,Theo H. Smit +7 more
TL;DR: It is argued that mechanics and biology are interconnected and amplify each other and the proposed disease model explains the comparable efficacy of very different animal models of disc degeneration, but also helps to consider the consequences of therapeutic interventions, either at the cellular, material or mechanical level.
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Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration
Stephen M. Richardson,Gauthaman Kalamegam,Peter Natesan Pushparaj,Csaba Matta,Adnan Memic,Ali Khademhosseini,Reza Mobasheri,Fabian L Poletti,Judith A. Hoyland,Judith A. Hoyland,Ali Mobasheri,Ali Mobasheri,Ali Mobasheri +12 more
TL;DR: This review explores the exciting opportunities afforded by MSCs and discusses the challenges associated with cartilage and IVD repair and regeneration and the optimistic view that interdisciplinary approaches will lead to significant breakthroughs in regenerating musculoskeletal tissues in the near future.
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3D-Printed ABS and PLA Scaffolds for Cartilage and Nucleus Pulposus Tissue Regeneration.
TL;DR: It is demonstrated that chondrocytes and NP cells can proliferate on both ABS and PLA scaffolds printed with a simplistic, inexpensive desktop 3D printer, indicating that cells maintain individual phenotype over the three-week culture period.
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Biomaterials for intervertebral disc regeneration and repair.
Robby D. Bowles,Lori A. Setton +1 more
TL;DR: In this article, the authors review bioengineering advances to treat disc disorders, using cell-supplemented materials, or acellular, biologically based materials, that provide opportunity for cell-material interactions and remodeling in the treatment of intervertebral disc disorders.
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Molecular mechanisms of cell death in intervertebral disc degeneration (Review)
TL;DR: Recent progress in understanding the function and regulation of apoptosis and autophagy signaling pathways is summarized and studies that reveal the functional mechanisms of these pathways in IVD degeneration are focused on.
References
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What is intervertebral disc degeneration, and what causes it?
TL;DR: To suggest how intervertebral disc degeneration might be distinguished from the physiologic processes of growth, aging, healing, and adaptive remodeling, and to simplify the issue of causality.
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The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.
John Antoniou,Thomas Steffen,Fred Nelson,Neil Winterbottom,Anthony P. Hollander,Robin A. Poole,Max Aebi,Mauro Alini +7 more
TL;DR: Three matrix turnover phases are identified and evidence is illustrated for a lack of increased synthesis of aggrecan and type II procollagen, but also by an increase in collagen type II denaturation and type I Procollagen synthesis, both dependent on age and grade of tissue degeneration.
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Nutrition of the intervertebral disc.
TL;DR: Loss of nutrient supply can lead to cell death, loss of matrix production, and increase in matrix degradation and hence to disc degeneration.
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Clinical spinal instability and low back pain
TL;DR: Concerning the role of neuromuscular control system, increased body sway has been found in patients with low back pain, indicating a less efficient muscle control system with decreased ability to provide the needed spinal stability.
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Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks.
TL;DR: In this work, hyaluronic acid with molecular weights ranging from 50 to 1100 kDa was modified with methacrylic anhydride and photopolymerized into networks with a wide range of physical properties, which presented a next step toward the development of advanced in vivo curable biomaterials.