Journal ArticleDOI
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders.
Annamaria Vallelunga,Raffaella Flaibani,Patrizia Formento-Dojot,Roberta Biundo,Silvia Facchini,Angelo Antonini +5 more
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TLDR
Polymorphisms of dopaminergic genes do not play a relevant role in the development of ICD in PD suggesting that ICD originate from inability to filter inappropriate behaviors triggered by dopaminaergic therapy.About:
This article is published in Parkinsonism & Related Disorders.The article was published on 2012-05-01. It has received 61 citations till now. The article focuses on the topics: rs4680 & Catechol-O-methyl transferase.read more
Citations
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Journal ArticleDOI
Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.
Valerie Voon,Valerie Voon,T. Celeste Napier,Michael J. Frank,Véronique Sgambato-Faure,Véronique Sgambato-Faure,Anthony A. Grace,Maria C. Rodriguez-Oroz,Maria C. Rodriguez-Oroz,Jose A. Obeso,Jose A. Obeso,Erwan Bezard,Erwan Bezard,Pierre-Olivier Fernagut,Pierre-Olivier Fernagut +14 more
TL;DR: In patients with Parkinson's disease and impulse control disorders, impairments are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the relative balance of rewards and losses.
Book ChapterDOI
Impulse Control and Related Disorders in Parkinson's Disease.
TL;DR: It is critical for patients to be monitored closely for impulse control disorders from disease onset and routine throughout its course, and as empirically validated treatments for ICDs and similar disorders emerge, it will also be important to examine their efficacy and tolerability in individuals with comorbid PD.
Journal ArticleDOI
Dopamine Agonists and Impulse Control Disorders: A Complex Association.
Marie Grall-Bronnec,Caroline Victorri-Vigneau,Yann Donnio,Juliette Leboucher,Morgane Rousselet,Elsa Thiabaud,Nicolas Zreika,Pascal Derkinderen,Gaëlle Challet-Bouju +8 more
TL;DR: It is suggested that DAA use is associated with an increased risk in the occurrence of an ICD, under the combined influence of various factors.
Journal ArticleDOI
Clinical-genetic model predicts incident impulse control disorders in Parkinson's disease
Julia Kraemmer,Julia Kraemmer,Kara M. Smith,Daniel Weintraub,Daniel Weintraub,Vincent Guillemot,Mike A. Nalls,Florence Cormier-Dequaire,Ivan Moszer,Alexis Brice,Andrew B. Singleton,Jean-Christophe Corvol +11 more
TL;DR: The results show that adding a candidate genetic panel increases ICD predictability, suggesting potential for developing clinical-genetic models to identify patients with PD at increased risk of ICD development and guide DRT management.
Journal ArticleDOI
Impulse control and related disorders in Parkinson's disease.
TL;DR: It is critical for patients to be monitored closely for their development of impulse control disorders, as empirically validated treatments for ICDs emerge, and it will also be important to examine their efficacy and tolerability in individuals with comorbid PD.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.