Journal ArticleDOI
Role of human lipocalin proteins in abdominal obesity after acute pancreatitis.
TLDR
Findings indicate that circulating levels of LCN‐2 in patients after AP may play a role in chronic low grade inflammation associated with abdominal adiposity and that alcohol consumption may further exacerbate adipose tissue dysfunction.About:
This article is published in Peptides.The article was published on 2017-05-01. It has received 26 citations till now. The article focuses on the topics: Abdominal obesity & Retinol binding protein 4.read more
Citations
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Journal ArticleDOI
Global epidemiology and holistic prevention of pancreatitis.
Maxim S. Petrov,Dhiraj Yadav +1 more
TL;DR: This Review provides precise and up-to-date data on the burden of acute pancreatitis, chronic pancreatitis and post-pancreatitis diabetes mellitus, and introduces a framework for the holistic prevention of pancreatitis with a view to providing guidance on strategies and intervention objectives at primary, secondary and tertiary levels.
Journal ArticleDOI
The role of osteoblasts in energy homeostasis
Naomi Dirckx,Megan C. Moorer,Megan C. Moorer,Thomas L. Clemens,Thomas L. Clemens,Ryan C. Riddle,Ryan C. Riddle +6 more
TL;DR: The current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans are summarized, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteobllast differentiation.
Journal ArticleDOI
Ectopic fat accumulation in the pancreas and its biomarkers: A systematic review and meta‐analysis
TL;DR: Circulating levels of triglycerides and glycated haemoglobin appear to be the best currently available markers of pancreaticFat in blood, and the approach of non‐invasive and accurate detection of pancreas fat by blood analysis should be further explored in the future.
Journal ArticleDOI
Update on the human and mouse lipocalin ( LCN ) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”
Georgia Charkoftaki,Yewei Wang,Monica S. McAndrews,Elspeth A. Bruford,David C. Thompson,Vasilis Vasiliou,Daniel W. Nebert +6 more
TL;DR: Although much has been learned about LCNs and MUPs in recent years, more research is necessary to allow better understanding of their physiological functions, as well as their involvement in clinical disorders.
Journal ArticleDOI
Trajectories of glycaemia following acute pancreatitis: a prospective longitudinal cohort study with 24 months follow-up.
Sakina H. Bharmal,Jaelim Cho,Gisselle C. Alarcon Ramos,Juyeon Ko,Charlotte E Stuart,Andre E Modesto,Ruma G. Singh,Maxim S. Petrov +7 more
TL;DR: This first prospective cohort study of changes in glycaemia showed that at least one out of five patients develops new-onset prediabetes or diabetes at 6 months of follow-up and more than four out of ten—in the first 2 years.
References
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Journal ArticleDOI
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
William C. Taylor,Nigel Unwin +1 more
Journal ArticleDOI
Elevated C-reactive protein levels in overweight and obese adults.
TL;DR: Higher BMI is associated with higher CRP concentrations, even among young adults aged 17 to 39 years, and these findings suggest a state of low-grade systemic inflammation in overweight and obese persons.
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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Qin Yang,Timothy E. Graham,Nimesh Mody,Frédéric Preitner,Odile D. Peroni,Janice M. Zabolotny,Ko Kotani,Loredana Quadro,Barbara B. Kahn +8 more
TL;DR: It is shown that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4-/- mice and RBP4 is an adipocyte-derived ‘signal’ that may contribute to the pathogenesis of type 2 diabetes.
Journal ArticleDOI
Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program
TL;DR: Three cases illustrate that pentoxifylline, in conjunction with intensive therapy for diabetes, may be particularly useful in reducing significant proteinuria in patients with macroalbuminuria from diabetic nephropathy.