Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
Reads0
Chats0
TLDR
In this article , the role of RNA modifications in cancer progression has become increasingly prominent and is a hot spot in scientific research, which refers to heritable modifications in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes.Abstract:
Abstract Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes. Epigenetic modifications regulate many biological processes, such as growth, aging, and various diseases, including cancer. With the advancement of next-generation sequencing technology, the role of RNA modifications in cancer progression has become increasingly prominent and is a hot spot in scientific research. This review studied several common RNA modifications, such as N 6 -methyladenosine, 5-methylcytosine, and pseudouridine. The deposition and roles of these modifications in coding and noncoding RNAs are summarized in detail. Based on the RNA modification background, this review summarized the expression, function, and underlying molecular mechanism of these modifications and their regulators in cancer and further discussed the role of some existing small-molecule inhibitors. More in-depth studies on RNA modification and cancer are needed to broaden the understanding of epigenetics and cancer diagnosis, treatment, and prognosis. read more
Citations
More filters
Journal ArticleDOI
RNA modifications: importance in immune cell biology and related diseases
Lian Cui,Rui Ma,Jiangli Cai,Chunyuan Guo,Zeyu Chen,Lina Yao,Yuanyuan Wang,Rui Fan,Xin Wang,Yuling Shi +9 more
TL;DR: In this article , the authors present existing knowledge of the biological functions and underlying mechanisms of RNA modifications, including N 6 -methyladenosine (m 6 A), 5-methylcytosine(m 5 C), N 1 -methyl adenosine,m 1 A), N 7 -methylguanosine (n 7 G), N 4 -acetylacetylcytusine (ac 4 C), pseudouridine (Ψ), uridylation, and A-to-I RNA editing, and summarize their critical roles in immune cell biology and highlight the challenges and future directions based on the existing knowledge.
Journal ArticleDOI
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities
TL;DR: The central mechanisms by which epigenetics and metabolism reciprocally modulate each other in cancer are summarized and elaborate upon and update the major contributions of the interplays between epigenetic aberrations and metabolic rewiring to cancer initiation and development.
Journal ArticleDOI
The Epitranscriptomic Mechanism of Metal Toxicity and Carcinogenesis
Chengfeng Yang,Zhishan Wang +1 more
TL;DR: The goal of this review is to discuss recent studies on the epitranscriptomic effects of metals and propose some thoughts for future studies in the field.
Journal ArticleDOI
Genetic and epigenetic defects of the RNA modification machinery in cancer.
TL;DR: The role of RNA modification machinery is often altered in human cancers, highlighting the enormous potential of RNA-modifying proteins (RMPs) as pharmacological targets or diagnostic markers as discussed by the authors .
Journal ArticleDOI
Icariin as an emerging candidate drug for anticancer treatment: Current status and perspective.
Yufang Liu,Han Yang,Jie Xiong,Juanjuan Zhao,Mengmeng Guo,Jing M. Chen,Xu Zhao,Chao Chen,Zhixu He,Ya Zhou,Lin Xu +10 more
TL;DR: In this paper , the authors systematically summarized the current research progress of ICA in a series of cancers, including breast cancer, colorectal cancer, hepatocellular carcinoma, esophageal cancer and other cancers.
References
More filters
Journal ArticleDOI
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
Journal ArticleDOI
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
Cancer statistics, 2019.
TL;DR: The overall cancer death rate dropped continuously from 1991 to 2016 by a total of 27%, translating into approximately 2,629,200 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
Cancer statistics, 2018
TL;DR: The combined cancer death rate dropped continuously from 1991 to 2015 by a total of 26%, translating to approximately 2,378,600 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.