Journal ArticleDOI
Role of MICA in the immune response to transplants.
Y. Zou,Peter Stastny +1 more
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TLDR
Typing of recipients and donors by sequencing the MICA alleles has established that de novo antibodies produced in kidney transplant recipients are directed at mismatched MICA epitopes and are associated with acute rejection and chronic transplant failure.Abstract:
Among the cell surface antigens that can elicit an immune response in transplant recipients MICA antigens occupy a special place They are similar to human leukocyte antigens (HLAs) while being very different from them They are not as polymorphic and their quantity is smaller In consequence, the impact of MICA antigens in transplantation is not as dramatic However, our early guess that these ligands of NKG2D could elicit antibodies and cell-mediated immunity has been definitely confirmed Careful analysis with MICA transfectant cells, for absorption and elution, established the specificity of the epitopes involved Typing of recipients and donors by sequencing the MICA alleles has established that de novo antibodies produced in kidney transplant recipients are directed at mismatched MICA epitopes and are associated with acute rejection and chronic transplant failure Acute graft-versus-host disease was observed in stem cell recipients who were mismatched for MICAread more
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The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation
Antje Isernhagen,Dörthe Malzahn,Elena Viktorova,Leslie Elsner,Sebastian Monecke,Frederike von Bonin,Markus Kilisch,Janne Marieke Wermuth,Neele Walther,Yesilda Balavarca,Christiane Stahl-Hennig,Michael Engelke,Lutz Walter,Heike Bickeböller,Dieter Kube,Gerald Wulf,Ralf Dressel +16 more
TL;DR: Overall survival of MICA‐129Val/Val genotype carriers was improved when treated with anti‐thymocyte globulin and reduced the risk to die due to acute graft‐versus‐host disease (aGVHD) and the reduced cell surface expression of NKG2D in response to engagement by Mica‐129Met variants appeared to reduce the severity of aGVHD.
Journal ArticleDOI
Role of non-HLA antibodies in organ transplantation.
TL;DR: Paradigms for effective monitoring of non-HLA humoral responses need to be established in order to utilize advances provided by the rapid diagnostic developments, and a systematic longitudinal assessment of pretransplant sensitization together with monitoring of posttransplant changes would represent an important step forward.
Journal ArticleDOI
Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation
Steven T. Cox,Henry A.F. Stephens,Henry A.F. Stephens,R Fernando,R Fernando,Aliyye Karasu,Aliyye Karasu,M Harber,Alexander J. Howie,Stephen H. Powis,Yizhou Zou,Peter Stastny,J. Alejandro Madrigal,Ann Margaret Little +13 more
TL;DR: It is concluded that mismatching for MICA epitopes in renal transplantation is a mechanism leading to production of MICA antibodies that associate with acute rejection (AR) and graft dysfunction by univariate and multivariate analysis.
Journal ArticleDOI
HLA and MICA polymorphism in Polynesians and New Zealand Maori: implications for ancestry and health.
Hisham Atan Edinur,P. P. J. Dunn,L. Hammond,Caroline Selwyn,P. Brescia,Medhat Askar,Patrick K. Reville,Z. Velickovic,Z. Velickovic,Rodney A. Lea,Geoff Chambers +10 more
TL;DR: The wider significance of HLA and MICA allele frequencies across the Pacific for modern day health is discussed in terms of the frequency relative to reference populations of disease known to be associated with specific HLA or MICA markers.
Journal ArticleDOI
Expression of MHC class I-related molecules MICA, HLA-E and EPCR shape endothelial cells with unique functions in innate and adaptive immunity.
Pierre-Jean Gavlovsky,Pierre Tonnerre,Christophe Guitton,Béatrice Charreau,Béatrice Charreau +4 more
TL;DR: The role of EPCR, a key regulator of coagulation, as a ligand for a circulating subset of Vδ2- γδ T cells may also influence transplant outcome.
References
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Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
TL;DR: An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.
Journal ArticleDOI
Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.
TL;DR: A highly divergent human MHC class I molecule, MICA, encodes a cell surface glycoprotein, which is not associated with beta 2-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium.
Journal ArticleDOI
A second lineage of mammalian major histocompatibility complex class I genes
TL;DR: A second lineage of evolutionarily conserved MHC class I genes is defined and the presence of diagnostic residues in the MICA amino acid sequence translated from cDNA suggests that the putative MICA chain folds similarly to typical class I chains and may have the capacity to bind peptide or other short ligands.
Journal ArticleDOI
Antibodies against MICA Antigens and Kidney-Transplant Rejection
TL;DR: Presensitization of kidney-transplant recipients against MICA antigens is associated with an increased frequency of graft loss and might contribute to allograft loss among recipients who are well matched for HLA.
Journal ArticleDOI
MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes.
TL;DR: Although the function of MICA is still unknown, its restricted pattern of tissue expression, the fact that it is expressed on the cell surface, and its polymorphic nature suggest that this new molecule, encoded close to HLA class I, may play a role in the interaction between epithelial cells and cells of the immune system.