Rotors and the Dynamics of Cardiac Fibrillation
Sandeep V. Pandit,José Jalife +1 more
TLDR
Examination of recent evidence suggesting that rotors are critical in sustaining both atrial and ventricular fibrillation in the human heart and its implications for treatment with radiofrequency ablation is examined.Abstract:
The objective of this article is to present a broad review of the role of cardiac electric rotors and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset, we present a brief historical overview regarding reentry and then discuss the basic concepts and terminologies pertaining to rotors and their initiation. Thereafter, the intrinsic properties of rotors and spiral waves, including phase singularities, wavefront curvature, and dominant frequency maps, are discussed. The implications of rotor dynamics for the spatiotemporal organization of fibrillation, independent of the species being studied, are described next. The knowledge gained regarding the role of cardiac structure in the initiation or maintenance of rotors and the ionic bases of spiral waves in the past 2 decades, as well as the significance for drug therapy, is reviewed subsequently. We conclude by examining recent evidence suggesting that rotors are critical in sustaining both atrial and ventricular fibrillation in the human heart and its implications for treatment with radiofrequency ablation.read more
Citations
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Journal ArticleDOI
Mapping of ventricular arrhythmias using a novel noninvasive epicardial and endocardial electrophysiology system.
Alexey Tsyganov,Erik Wissner,Andreas Metzner,S. Mironovich,Maria Chaykovskaya,Vitaly Kalinin,Mikhail Chmelevsky,Christine Lemes,Karl-Heinz Kuck +8 more
TL;DR: Noninvasive cardiac mapping was able to visualize the macro-reentrant circuits in patients with scar-related VT and without myocardial scar, and rotor activity and multiple wavelets were observed.
Journal ArticleDOI
Rotor mapping and ablation to treat atrial fibrillation.
TL;DR: It is proposed that mapping localized sources for human atrial fibrillation, specifically rotors, is moving the field towards a unifying hypothesis that explains several otherwise contradictory observations in atrialfibrillation management.
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Catheter Ablation of Ventricular Fibrillation.
Robert D. Anderson,Saurabh Kumar,Jonathan M. Kalman,Prashanthan Sanders,Frederic Sacher,Mélèze Hocini,Pierre Jaïs,Michel Haïsaguerre,Geoffrey Lee +8 more
TL;DR: This review will focus on updates in elucidating the mechanism of VF leading into the role and indication of CA as a treatment strategy.
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Noninvasive Mapping and Electrocardiographic Imaging in Atrial and Ventricular Arrhythmias (CardioInsight).
Ghassen Cheniti,Stéphane Puyo,Claire Martin,Antonio Frontera,Konstantinos Vlachos,Masateru Takigawa,Felix Bourier,Takeshi Kitamura,Anna Lam,Carole Dumas-Pommier,Xavier Pillois,Thomas Pambrun,Josselin Duchateau,Nicolas Klotz,Arnaud Denis,Nicolas Derval,Hubert Cochet,Frederic Sacher,Rémi Dubois,Pierre Jaïs,Mélèze Hocini,Michel Haïssaguerre +21 more
TL;DR: Focal breakthroughs demonstrate a QS pattern associated with centrifugal activation and a unique opportunity to better understand the mechanism of cardiac arrhythmias and guide ablation.
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TL;DR: In vivo animal model and human atrial specimens used to further characterize the role of Ang II/JAK/STAT3 signaling pathway in the atrial structural remodeling support the key role ofAng II in the development of AF and highlight the specific mechanisms and changes associated with this process.
References
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Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
Michel Haïssaguerre,Pierre Jaïs,D. C. Shah,Atsushi Takahashi,Mélèze Hocini,G Quiniou,S. Garrigue,A Le Mouroux,P Le Métayer,Jacques Clementy +9 more
TL;DR: The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation and these foci respond to treatment with radio-frequency ablation.
Book
Cardiac Electrophysiology : From Cell to Bedside
Douglas P. Zipes,José Jalife +1 more
TL;DR: Part I - Molecular Bases Of Ion Channel Activity PART II - Biophysics and Regulation of Cardiac Ion Channels PART III - Pharmacology of Card cardiac Ion Ch channels PART IV - Cellular Electrophysiology PART V - Models of Cardiopulmonary Excitation PART VI - Neural Control ofCardiac Electrical Activity
Journal ArticleDOI
Excitation-Contraction Coupling and Cardiac Contractile Force.
Donald M. Bers,Yujie Zhu +1 more
TL;DR: The major cellular structures involved in E-C coupling include myofilaments, Na/Ca exchange and the sarcolemmal Ca-pump as mentioned in this paper, as well as the sources and sinks of activator calcium.
Journal ArticleDOI
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.
Ching-Hsing Luo,Yoram Rudy +1 more
TL;DR: The model provides the basis for the study of arrhythmogenic activity of the single myocyte including afterdepolarizations and triggered activity and can simulate cellular responses under different degrees of Ca2+ overload.
Journal ArticleDOI
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
Ching-Hsing Luo,Yoram Rudy +1 more
TL;DR: Simulation of the membrane action potential of the mammalian ventricular cell shows the importance of the slow recovery of INa in determining the response of the cell and relates these phenomena to the underlying ionic channel kinetics.