Running enhances neurogenesis, learning, and long-term potentiation in mice
TLDR
The results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.Abstract:
Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain structure that is important for memory function. Consequently, spatial learning and long-term potentiation (LTP) were tested in groups of mice housed either with a running wheel (runners) or under standard conditions (controls). Mice were injected with bromodeoxyuridine to label dividing cells and trained in the Morris water maze. LTP was studied in the dentate gyrus and area CA1 in hippocampal slices from these mice. Running improved water maze performance, increased bromodeoxyuridine-positive cell numbers, and selectively enhanced dentate gyrus LTP. Our results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.read more
Citations
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Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
TL;DR: Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
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Mechanisms and functional implications of adult neurogenesis.
TL;DR: The factors that regulate proliferation and fate determination of adult neural stem cells are discussed and the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease is addressed.
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Be smart, exercise your heart: exercise effects on brain and cognition
TL;DR: A growing number of studies support the idea that physical exercise is a lifestyle factor that might lead to increased physical and mental health throughout life, at the molecular, cellular, systems and behavioural levels.
Journal ArticleDOI
Functional neurogenesis in the adult hippocampus
Henriette van Praag,Alejandro F. Schinder,Brian R. Christie,Brian R. Christie,Nicolas Toni,Theo D. Palmer,Theo D. Palmer,Fred H. Gage +7 more
TL;DR: It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.
References
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A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Developments of a water-maze procedure for studying spatial learning in the rat
TL;DR: Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described, suggesting that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function.
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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.
TL;DR: It is demonstrated that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus, in amounts similar to enrichment conditions.
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More hippocampal neurons in adult mice living in an enriched environment
TL;DR: It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus.
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Learning enhances adult neurogenesis in the hippocampal formation.
TL;DR: It is reported that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus, which indicates that adult- generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.