Journal ArticleDOI
Safety and Efficacy of Apixaban Versus Warfarin in Patients With Advanced Chronic Kidney Disease.
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TLDR
Patients with advanced CKD taking apixaban had similar bleeding rates at 3 months compared with those taking warfarin, however, those who continued therapy had higher major bleeding rates with warFarin between 6 and 12 months.Abstract:
Background: Because of a lack of comparative data on anticoagulant use in the advanced chronic kidney disease (CKD) population, guidelines recommend warfarin for atrial fibrillation and venous thro...read more
Citations
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Journal ArticleDOI
2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation
Jan Steffel,Ronan Collins,Matthias Antz,Pieter Cornu,Lien Desteghe,Karl Georg Haeusler,Jonas Oldgren,Holger Reinecke,Vanessa Roldan-Schilling,Nigel Rowell,Peter Sinnaeve,Thomas Vanassche,Tatjana S. Potpara,A. John Camm,Hein Heidbuchel,External reviewers,Gregory Y.H. Lip,Gregory Y.H. Lip,T. Deneke,Nikolaos Dagres,Giuseppe Boriani,Tze-Fan Chao,Eue Keun Choi,Mellanie True Hills,Itamar S. Santos,Deirdre A. Lane,Deirdre A. Lane,Dan Atar,Boyoung Joung,Oana Maria Cole,Mark Field +30 more
Journal ArticleDOI
Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review
TL;DR: A systematic review summarizes and evaluates DOACs use in real‐world practice and indicates discordance between guidelines and real-world practice regarding direct oral anticoagulant drug doses.
Journal ArticleDOI
Risk of Major Gastrointestinal Bleeding With New vs Conventional Oral Anticoagulants: A Systematic Review and Meta-analysis.
Zhi-Chun Gu,An-Hua Wei,Chi Zhang,Xin-Hua Wang,Le Zhang,Long Shen,Zheng Li,Mang-Mang Pan,Xiao-Yan Liu,Jun Pu,Hou-Wen Lin +10 more
TL;DR: It is confirmed that there is no significant difference in risk of major GIB between patients receiving NOACs vs conventional treatment and meta-regression analysis failed to detect any potential confounding to impact the primacy outcome.
Journal ArticleDOI
Role of direct oral anticoagulants in patients with kidney disease
TL;DR: The currently available literature on DOAC use in kidney disease is summarized and knowledge gaps that represent important opportunities for prospective investigation are illustrated.
Journal ArticleDOI
Outcomes associated with apixaban vs warfarin in patients with renal dysfunction.
Claudia Hanni,Elizabeth Petrovitch,Mona Ali,Whitney Gibson,Christopher Giuliano,Jenna Holzhausen,Charles T Makowski,Amy Pallisco,Nisha Patel,Denise Sutter,Long To,Raymond Yost +11 more
TL;DR: Apixaban may serve as a reasonable alternative compared with warfarin in patients with severe renal dysfunction and risk of thrombotic and bleeding events was lower in the apixaban group, and the severity of bleeding and thromBotic events was not different between groups.
References
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Journal ArticleDOI
A New Equation to Estimate Glomerular Filtration Rate
Andrew S. Levey,Lesley A. Stevens,Christopher H. Schmid,Yaping (Lucy) Zhang,Alejandro F. Castro,Harold I. Feldman,John W. Kusek,Paul W. Eggers,Frederick Van Lente,Tom Greene,Josef Coresh +10 more
TL;DR: The CKD-EPI creatinine equation is more accurate than the Modification of Diet in Renal Disease Study equation and could replace it for routine clinical use.
Journal ArticleDOI
Dabigatran versus warfarin in patients with atrial fibrillation
Stuart J. Connolly,Michael D. Ezekowitz,John W. Eikelboom,Jonas Oldgren,Amit Parekh,Janice Pogue,Paul A. Reilly,Ellison Themeles,Jeanne Varrone,Susan Wang,Marco Alings,Denis Xavier,Jun Zhu,Rafael Diaz,Basil S. Lewis,Harald Darius,Hans-Christoph Diener,Campbell D. Joyner,Lars Wallentin +18 more
TL;DR: In patients with atrial fibrillation, dabigatran given at a dose of 110 mg was associated with rates of stroke and systemic embolism that were similar to those associated with warfarin, as well as lower rates of major hemorrhage.
Journal ArticleDOI
Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation
Manesh R. Patel,Kenneth W. Mahaffey,Jyotsna Garg,Guohua Pan,Daniel E. Singer,Werner Hacke,Günter Breithardt,Jonathan L. Halperin,Graeme J. Hankey,Jonathan P. Piccini,Richard C. Becker,Christopher C. Nessel,John F. Paolini,Scott D. Berkowitz,Robert M. Califf +14 more
TL;DR: In patients with atrial fibrillation, rivaroxaban was noninferior to warfarin for the prevention of stroke or systemic embolism and there was no significant between-group difference in the risk of major bleeding, although intracranial and fatal bleeding occurred less frequently in the rivroxaban group.
Journal ArticleDOI
Apixaban versus Warfarin in Patients with Atrial Fibrillation
Christopher B. Granger,John H. Alexander,Renato D. Lopes,Elaine M. Hylek,Michael G. Hanna,Hussein R. Al-Khalidi,Jack Ansell,Dan Atar,Alvaro Avezum,M. Cecilia Bahit,Rafael Diaz,J. Donald Easton,Justin A. Ezekowitz,Greg C. Flaker,David A. Garcia,Margarida Geraldes,Bernard J. Gersh,Sergey P. Golitsyn,Shinya Goto,Antonio G. Hermosillo,Stefan H. Hohnloser,John D. Horowitz,Puneet Mohan,Petr Jansky,Basil S. Lewis,Jose Lopez-Sendon,Prem Pais,Alexander Parkhomenko,Jun Zhu,Lars Wallentin +29 more
TL;DR: In patients with atrial fibrillation, apixaban was superior to warfarin in preventing stroke or systemic embolism, caused less bleeding, and resulted in lower mortality.
Journal ArticleDOI
Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report
Clive Kearon,Elie A. Akl,Elie A. Akl,Joseph Ornelas,Allen J. Blaivas,David Jiménez,Henri Bounameaux,Menno V. Huisman,Christopher S. King,Timothy A. Morris,Namita Sood,Scott M. Stevens,Janine R.E. Vintch,Philip S. Wells,Scott C. Woller,Lisa K. Moores +15 more
TL;DR: Recommendations on 12 topics that were in the 9th edition of these guidelines are updated, and 3 new topics are addressed.
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