Journal ArticleDOI
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: Dermal, acute and short-term toxicity studies
Reads0
Chats0
TLDR
From these studies a no-observed adverse effect level of 500 mg EGCG preparation/kg/day was established, and this dose caused morbidity when administered to fasted dogs as a single bolus dose, although this model was considered an unrealistic comparison to the human condition.About:
This article is published in Food and Chemical Toxicology.The article was published on 2006-05-01. It has received 285 citations till now. The article focuses on the topics: Green tea extract & Epigallocatechin gallate.read more
Citations
More filters
Journal ArticleDOI
Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability.
TL;DR: This review summarizes the latest research in cancer chemoprevention and treatment using the bioactive components from natural plants and relevant molecular mechanisms involved in the pharmacological effects of these phytochemicals are discussed.
Journal ArticleDOI
Plants as sources of new antimicrobials and resistance-modifying agents
TL;DR: The aim of this article is to review the advances in in vitro and in vivo studies on the potential chemotherapeutic value of phytochemical products and plant extracts as RMAs to restore the efficacy of antibiotics against resistant pathogenic bacteria.
Journal ArticleDOI
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
TL;DR: This review highlights the literature surrounding this topic on the prominently studied and documented polyphenols as pertaining to cardiovascular health and aging.
Journal ArticleDOI
Hepatotoxicity of High Oral Dose (-)-Epigallocatechin-3-Gallate in Mice
TL;DR: The results indicate that higher bolus doses of EGCG are hepatotoxic to mice, which is important given the increasing use of green tea dietary supplements, which may deliver much higher plasma and tissue concentrations of E GCG than tea beverages.
Journal ArticleDOI
Hepatotoxicity from green tea: a review of the literature and two unpublished cases
Gabriela Mazzanti,Francesca Menniti-Ippolito,Paola Angela Moro,Federica Cassetti,Roberto Raschetti,Carmela Santuccio,Sabina Mastrangelo +6 more
TL;DR: The authors' analysis of the published case reports suggests a causal association between green tea and liver damage, probably due to (-)-epigallocatechin gallate or its metabolites which, under particular conditions related to the patient’s metabolism, can induce oxidative stress in the liver.
References
More filters
Journal ArticleDOI
Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.
Jane V. Higdon,Balz Frei +1 more
TL;DR: The effects of tea and green tea catechins on biomarker of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited.
Oecd guideline for testing of chemicals
TL;DR: The comet assay has been reviewed and recommendations have been published by various expert groups and this Test Guideline provides succinct and useful guidance to users of these Test Guidelines.
Journal ArticleDOI
The Identification of Contact Allergens by Animal Assay. the Guinea Pig Maximization Test
TL;DR: The guinea pig is the laboratory animal par excellence for the establishment of allergic contact sensitization and is the main source of knowledge of this form of delayed hypersensitivity.
Journal Article
Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.
H-H. Sherry Chow,Yan Cai,Iman A. Hakim,James A. Crowell,Farah Shahi,Chris Brooks,Robert T. Dorr,Yukihiko Hara,David S. Alberts +8 more
TL;DR: It is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8-16 cups of green tea once a day or in divided doses twice a day for 4 weeks, and the pharmacokinetics of the conjugated metabolites of epigallocatechin and epicatechin were not affected by repeated green teapolyphenol treatment.
Journal Article
Analysis of plasma and urinary tea polyphenols in human subjects.
TL;DR: Methods for the analysis of tea polyphenols in human plasma and urine samples using HPLC with the coulochem electrode array detection system to develop biomarkers for tea consumption established good quantitative relationships for a large concentration range of teapolyphenols.