Scaffold-free and scaffold-based cellular strategies and opportunities for cornea tissue engineering
Zahid Hussain,Renjun Pei +1 more
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This article is published in Progress in Biomedical Engineering.The article was published on 2021-07-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Scaffold & Tissue engineering.read more
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Journal Article
Limbal Biopsy Derived Stromal Stem Cells Prevent Corneal Scarring
TL;DR: Direct treatment of corneal scarring is investigated using autologous stem cells, a therapy that, if successful, could reduce the need for Corneal grafts.
Journal Article
N-Cadherin is Expressed by Putative Stem/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche
Ryuhei Hayashi,Masayuki Yamato,Hiroaki Sugiyama,T. Sumide,Joseph Yang,Teruo Okano,Yasuo Tano,Kohji Nishida +7 more
TL;DR: In this article, the authors demonstrate that N-cadherin is expressed by putative stem/progenitor cells, as well as melanocytes, in the human limbal epithelial stem cell niche.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice - eScholarship
Hongshan Liu,Jianhua Zhang,Chia-Yang Liu,I-Jong Wang,Martin A. Sieber,John T. Chang,James V. Jester,Winston W.-Y. Kao +7 more
TL;DR: Wang et al. as discussed by the authors used mesenchymal stem cells from neonatal umbilical cords to treat thin and cloudy corneas of lumican null mice, which significantly improved corneal transparency and increased stromal thickness.
Journal Article
ROCK inhibitor enhances adhesion and wound healing on human corneal endothelial cells
TL;DR: It is demonstrated for the first time in human corneal endothelial cells ex vivo and in vitro, that ROCK inhibitor did not induce any toxicity effect and did not alter cell viability, and its absence of toxicity, as demonstrated herein, is relevant for its use in human therapy.
Journal Article
Differentiation Potential of Limbal Fibroblasts and Bone Marrow Mesenchymal Stem Cells to Corneal Epithelial Cells
TL;DR: Reprogramming stage‐specific embryonic antigen‐4 (SSEA4+) LFs and BM MSCs are reprogramed into corneal epithelial lineage using a three‐dimensional culture system and embryonic stem cell medium to investigate the molecular mechanism involved in maintaining a limbal stem cell niche and thus a potentially important clinical application to treat cornean epithelial stem cell loss.
References
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Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells.
Jessica L. Rausch,Areej A. Ali,Donna M. Lee,Yemarshet K. Gebreyohannes,Keith R. Mehalek,Aya Agha,Sneha S. Patil,Yanis Tolstov,Jasmien Wellens,Harbir S. Dhillon,Kathleen R. Makielski,Maria Debiec-Rychter,Patrick Schöffski,Agnieszka Wozniak,Anette Duensing +14 more
TL;DR: 20S proteasome inhibitors are confirmed as promising strategy to overcome TKI resistance in GIST, while highlighting the complexity of the ubiquitin-proteasome machinery as a therapeutic target.
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Successful transplantation of in vitro expanded human cadaver corneal endothelial precursor cells on to a cadaver bovine's eye using a nanocomposite gel sheet.
Periyasamy Parikumar,Kazutoshi Haraguchi,Akira Ohbayashi,Rajappa Senthilkumar,Samuel J. K. Abraham +4 more
TL;DR: The use of the NC gel sheet makes HCEP cell transplantation feasible for human patients, and further in vitro basic studies followed by translational studies are necessary to bring this method for clinical application in appropriate indications.
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Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews.
Yonglong Guo,Yunxia Xue,Peiyuan Wang,Zekai Cui,Jixing Cao,Shiwei Liu,Quan Yu,Qiaolang Zeng,Deliang Zhu,Mengyuan Xie,Jun Zhang,Zhijie Li,Hongwei Liu,Jingxiang Zhong,Jiansu Chen +14 more
TL;DR: The results suggest that Muse-CSCs have therapeutic potential for treating corneal diseases and multilineage-differentiating stress-enduring (Muse) cells were isolated from lipoaspirate, which presented biphenotype properties of both pluripotent stem cells and some mesenchymal stem cells.
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Development of an Eye Model With a Physiological Blink Mechanism.
TL;DR: This model simulates a physiological blink actuation and an artificial tear film layer that could be used to study in vitro TBUT, tear deposition, and simple drug delivery.
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Mini-Sheet Injection for Cultured Corneal Endothelial Transplantation
TL;DR: It is demonstrated that the novel mini-sheet injection of corneal endothelial cells exhibited rapid adhesion, tight junction formation, andCorneal clarity recovery, which may represent a more efficient method for the transplantation of cultured corneals endothelium cells.