Scaffold-free and scaffold-based cellular strategies and opportunities for cornea tissue engineering
Zahid Hussain,Renjun Pei +1 more
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This article is published in Progress in Biomedical Engineering.The article was published on 2021-07-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Scaffold & Tissue engineering.read more
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Journal Article
Limbal Biopsy Derived Stromal Stem Cells Prevent Corneal Scarring
TL;DR: Direct treatment of corneal scarring is investigated using autologous stem cells, a therapy that, if successful, could reduce the need for Corneal grafts.
Journal Article
N-Cadherin is Expressed by Putative Stem/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche
Ryuhei Hayashi,Masayuki Yamato,Hiroaki Sugiyama,T. Sumide,Joseph Yang,Teruo Okano,Yasuo Tano,Kohji Nishida +7 more
TL;DR: In this article, the authors demonstrate that N-cadherin is expressed by putative stem/progenitor cells, as well as melanocytes, in the human limbal epithelial stem cell niche.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice - eScholarship
Hongshan Liu,Jianhua Zhang,Chia-Yang Liu,I-Jong Wang,Martin A. Sieber,John T. Chang,James V. Jester,Winston W.-Y. Kao +7 more
TL;DR: Wang et al. as discussed by the authors used mesenchymal stem cells from neonatal umbilical cords to treat thin and cloudy corneas of lumican null mice, which significantly improved corneal transparency and increased stromal thickness.
Journal Article
ROCK inhibitor enhances adhesion and wound healing on human corneal endothelial cells
TL;DR: It is demonstrated for the first time in human corneal endothelial cells ex vivo and in vitro, that ROCK inhibitor did not induce any toxicity effect and did not alter cell viability, and its absence of toxicity, as demonstrated herein, is relevant for its use in human therapy.
Journal Article
Differentiation Potential of Limbal Fibroblasts and Bone Marrow Mesenchymal Stem Cells to Corneal Epithelial Cells
TL;DR: Reprogramming stage‐specific embryonic antigen‐4 (SSEA4+) LFs and BM MSCs are reprogramed into corneal epithelial lineage using a three‐dimensional culture system and embryonic stem cell medium to investigate the molecular mechanism involved in maintaining a limbal stem cell niche and thus a potentially important clinical application to treat cornean epithelial stem cell loss.
References
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Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy.
TL;DR: Transplantation of in vitro expanded human corneal endothelial precursors (HCEP) cells using a nanocomposite (D25-NC) gel sheet as supporting material in bovine's cornea to three patients with bullous keratopathy and visual acuity improved in one of the patients by post-operative day 3 and was maintained at 18 months follow-up.
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Limbal stem cell diseases
TL;DR: The function of limbal stem/progenitor cells (LSCs) is critical to maintain corneal epithelial homeostasis Many external insults and intrinsic defects can be deleterious to LSCs and their niche micro-environment, resulting in Limbal stem cell dysfunction or deficiency as discussed by the authors.
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3D in vitro corneal models: A review of current technologies
TL;DR: Three major technologies are highlighted: organotypic cultures, organoids and 3D bioprinting, along with the disease relevance and potential applications of these models.
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Differentiation Induction of Human Stem Cells for Corneal Epithelial Regeneration.
Kasem Theerakittayakorn,Hong Thi Nguyen,Jidapa Musika,Hataiwan Kunkanjanawan,Sumeth Imsoonthornruksa,Sirilak Somredngan,Mariena Ketudat-Cairns,Rangsun Parnpai +7 more
TL;DR: The available protocols for inducing the differentiation of human stem cells into corneal epithelial cells are gathered and compared and the pathways involving in the differentiation are provided to elucidate the relevant mechanisms.
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Distinct and combined responses to environmental geometry and features in a working-memory reorientation task in rats and chicks.
Sang Ah Lee,Joseph M. Austen,Valeria Anna Sovrano,Giorgio Vallortigara,Anthony McGregor,Colin Lever +5 more
TL;DR: The original provocative formulation of the ‘geometric module’ hypothesis was based on a working-memory task in rats which suggested that spontaneous reorientation behavior is based solely on the environmental geometry and is impervious to featural cues, but here it is retested by returning to a spontaneous navigation task with rats and domestic chicks.