Scaffold-free and scaffold-based cellular strategies and opportunities for cornea tissue engineering
Zahid Hussain,Renjun Pei +1 more
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This article is published in Progress in Biomedical Engineering.The article was published on 2021-07-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Scaffold & Tissue engineering.read more
Citations
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Journal Article
Limbal Biopsy Derived Stromal Stem Cells Prevent Corneal Scarring
TL;DR: Direct treatment of corneal scarring is investigated using autologous stem cells, a therapy that, if successful, could reduce the need for Corneal grafts.
Journal Article
N-Cadherin is Expressed by Putative Stem/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche
Ryuhei Hayashi,Masayuki Yamato,Hiroaki Sugiyama,T. Sumide,Joseph Yang,Teruo Okano,Yasuo Tano,Kohji Nishida +7 more
TL;DR: In this article, the authors demonstrate that N-cadherin is expressed by putative stem/progenitor cells, as well as melanocytes, in the human limbal epithelial stem cell niche.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice - eScholarship
Hongshan Liu,Jianhua Zhang,Chia-Yang Liu,I-Jong Wang,Martin A. Sieber,John T. Chang,James V. Jester,Winston W.-Y. Kao +7 more
TL;DR: Wang et al. as discussed by the authors used mesenchymal stem cells from neonatal umbilical cords to treat thin and cloudy corneas of lumican null mice, which significantly improved corneal transparency and increased stromal thickness.
Journal Article
ROCK inhibitor enhances adhesion and wound healing on human corneal endothelial cells
TL;DR: It is demonstrated for the first time in human corneal endothelial cells ex vivo and in vitro, that ROCK inhibitor did not induce any toxicity effect and did not alter cell viability, and its absence of toxicity, as demonstrated herein, is relevant for its use in human therapy.
Journal Article
Differentiation Potential of Limbal Fibroblasts and Bone Marrow Mesenchymal Stem Cells to Corneal Epithelial Cells
TL;DR: Reprogramming stage‐specific embryonic antigen‐4 (SSEA4+) LFs and BM MSCs are reprogramed into corneal epithelial lineage using a three‐dimensional culture system and embryonic stem cell medium to investigate the molecular mechanism involved in maintaining a limbal stem cell niche and thus a potentially important clinical application to treat cornean epithelial stem cell loss.
References
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Ex Vivo Functionality of 3D Bioprinted Corneal Endothelium Engineered with Ribonuclease 5-Overexpressing Human Corneal Endothelial Cells.
TL;DR: The fabricated corneal endothelium with cultured HCECs easily survives and functions as corneals in vivo and the use of the cultured HCecs engineered to overexpress RNase 5 (R5‐HCECs) may be an option to obtain higher graft cellularity and to enhance the function of transplanted grafts.
Journal ArticleDOI
Biomimetic corneal stroma using electro-compacted collagen.
Zhi Chen,Xiao Liu,Jingjing You,Yihui Song,Eva Tomaskovic-Crook,Gerard Sutton,Jeremy M. Crook,Jeremy M. Crook,Jeremy M. Crook,Gordon G. Wallace +9 more
TL;DR: The 3D-CSM is a significant advance for synthetic corneal stroma engineering, with the potential to be used for full-thickness and functional cornea replacement, as well as informing in vivo tissue regeneration.
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Systematic Review and Meta-Analysis of the Medium- and Long-Term Outcomes of the Boston Type 1 Keratoprosthesis.
TL;DR: The 2-year results indicate that there is a place for the Boston type 1 KPro in the management of corneal blindness, and there is scarce evidence regarding its medium- and long-term efficacy and safety.
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Corneal epithelialisation on surface-modified hydrogel implants: artificial cornea.
Aihua Ma,Bojun Zhao,Adam J. Bentley,Arun Brahma,Sheila MacNeil,Francis Martin,Stephen Rimmer,Nigel J. Fullwood +7 more
TL;DR: Evaluation of the corneas implanted with the 1,4-diaminobutane-modified hydrogels coated with collagen IV showed that the artificial Corneas remain clear, integrate well and become covered by a healthy stratified epithelium.
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Optimization of Human Corneal Endothelial Cells for Culture: The Removal of Corneal Stromal Fibroblast Contamination Using Magnetic Cell Separation
TL;DR: Evaluating a strategy using magnetic cell separation (MACS) technique to deplete the contaminating CSFs from CEC cultures using antifibroblast magnetic microbeads found it useful in the depletion of contaminatingCSFs from within a culture of CECs.