Scaffold-free and scaffold-based cellular strategies and opportunities for cornea tissue engineering
Zahid Hussain,Renjun Pei +1 more
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This article is published in Progress in Biomedical Engineering.The article was published on 2021-07-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Scaffold & Tissue engineering.read more
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Journal Article
Limbal Biopsy Derived Stromal Stem Cells Prevent Corneal Scarring
TL;DR: Direct treatment of corneal scarring is investigated using autologous stem cells, a therapy that, if successful, could reduce the need for Corneal grafts.
Journal Article
N-Cadherin is Expressed by Putative Stem/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche
Ryuhei Hayashi,Masayuki Yamato,Hiroaki Sugiyama,T. Sumide,Joseph Yang,Teruo Okano,Yasuo Tano,Kohji Nishida +7 more
TL;DR: In this article, the authors demonstrate that N-cadherin is expressed by putative stem/progenitor cells, as well as melanocytes, in the human limbal epithelial stem cell niche.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice - eScholarship
Hongshan Liu,Jianhua Zhang,Chia-Yang Liu,I-Jong Wang,Martin A. Sieber,John T. Chang,James V. Jester,Winston W.-Y. Kao +7 more
TL;DR: Wang et al. as discussed by the authors used mesenchymal stem cells from neonatal umbilical cords to treat thin and cloudy corneas of lumican null mice, which significantly improved corneal transparency and increased stromal thickness.
Journal Article
ROCK inhibitor enhances adhesion and wound healing on human corneal endothelial cells
TL;DR: It is demonstrated for the first time in human corneal endothelial cells ex vivo and in vitro, that ROCK inhibitor did not induce any toxicity effect and did not alter cell viability, and its absence of toxicity, as demonstrated herein, is relevant for its use in human therapy.
Journal Article
Differentiation Potential of Limbal Fibroblasts and Bone Marrow Mesenchymal Stem Cells to Corneal Epithelial Cells
TL;DR: Reprogramming stage‐specific embryonic antigen‐4 (SSEA4+) LFs and BM MSCs are reprogramed into corneal epithelial lineage using a three‐dimensional culture system and embryonic stem cell medium to investigate the molecular mechanism involved in maintaining a limbal stem cell niche and thus a potentially important clinical application to treat cornean epithelial stem cell loss.
References
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Journal ArticleDOI
Ultrastructure of the Posterior Corneal Stroma
Ursula Schlötzer-Schrehardt,Bjoern O. Bachmann,Theofilos Tourtas,Andre A.M. Torricelli,Arun D. Singh,Sheyla González,Hua Mei,Sophie X. Deng,Steven E. Wilson,Friedrich E. Kruse +9 more
TL;DR: The findings did not provide any evidence for the existence of a distinctive acellular pre-Descemet's stromal layer in the human cornea, and the intrastromal cleavage plane after pneumodissection seems to be nonreproducibly determined by the intraindividually and interindividually variable distances of keratocytes to DesceMET's membrane.
Journal ArticleDOI
3D map of the human corneal endothelial cell.
Zhiguo He,Fabien Forest,Philippe Gain,Damien Rageade,Aurélien Bernard,Sophie Acquart,Michel Peoc'h,Dennis M. Defoe,Gilles Thuret +8 more
TL;DR: This first 3D map aids the understanding of the morphologic and functional specificity of CECs and could be used as a reference for characterizing future cell therapy products destined to treat endothelial dysfunctions.
Journal ArticleDOI
Generation of a Biomimetic Human Artificial Cornea Model Using Wharton's Jelly Mesenchymal Stem Cells
Ingrid Garzón,Miguel Angel Martin-Piedra,Camilo A. Alfonso‐Rodríguez,Miguel Gonzalez-Andrades,Víctor Carriel,Carlos Martínez-Gómez,Antonio Campos,Miguel Alaminos +7 more
TL;DR: The findings suggest that HWJSCs can be considered an alternative cell source for cornea regeneration and may offer a solution for patients with limbus stem cell deficiency.
Journal ArticleDOI
Five-Year Follow-up of First 11 Patients Undergoing Injection of Cultured Corneal Endothelial Cells for Corneal Endothelial Failure
Kohsaku Numa,Kojiro Imai,Morio Ueno,Koji Kitazawa,Hiroshi Tanaka,John Bush,Satoshi Teramukai,Naoki Okumura,Noriko Koizumi,Junji Hamuro,Chie Sotozono,Shigeru Kinoshita +11 more
TL;DR: The findings in this study confirmed the safety and efficacy of cultured hCEC-injection therapy for up to 5-years postoperative in a first-in-man clinical trial group.
Journal ArticleDOI
The limbal epithelium of the eye – A review of limbal stem cell biology, disease and treatment
TL;DR: The salient milestones of lim Bal stem cell biology and potential future treatments for limbal stem cell deficiency are highlighted.