Scaffold-free and scaffold-based cellular strategies and opportunities for cornea tissue engineering
Zahid Hussain,Renjun Pei +1 more
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This article is published in Progress in Biomedical Engineering.The article was published on 2021-07-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Scaffold & Tissue engineering.read more
Citations
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Journal Article
Limbal Biopsy Derived Stromal Stem Cells Prevent Corneal Scarring
TL;DR: Direct treatment of corneal scarring is investigated using autologous stem cells, a therapy that, if successful, could reduce the need for Corneal grafts.
Journal Article
N-Cadherin is Expressed by Putative Stem/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche
Ryuhei Hayashi,Masayuki Yamato,Hiroaki Sugiyama,T. Sumide,Joseph Yang,Teruo Okano,Yasuo Tano,Kohji Nishida +7 more
TL;DR: In this article, the authors demonstrate that N-cadherin is expressed by putative stem/progenitor cells, as well as melanocytes, in the human limbal epithelial stem cell niche.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice - eScholarship
Hongshan Liu,Jianhua Zhang,Chia-Yang Liu,I-Jong Wang,Martin A. Sieber,John T. Chang,James V. Jester,Winston W.-Y. Kao +7 more
TL;DR: Wang et al. as discussed by the authors used mesenchymal stem cells from neonatal umbilical cords to treat thin and cloudy corneas of lumican null mice, which significantly improved corneal transparency and increased stromal thickness.
Journal Article
ROCK inhibitor enhances adhesion and wound healing on human corneal endothelial cells
TL;DR: It is demonstrated for the first time in human corneal endothelial cells ex vivo and in vitro, that ROCK inhibitor did not induce any toxicity effect and did not alter cell viability, and its absence of toxicity, as demonstrated herein, is relevant for its use in human therapy.
Journal Article
Differentiation Potential of Limbal Fibroblasts and Bone Marrow Mesenchymal Stem Cells to Corneal Epithelial Cells
TL;DR: Reprogramming stage‐specific embryonic antigen‐4 (SSEA4+) LFs and BM MSCs are reprogramed into corneal epithelial lineage using a three‐dimensional culture system and embryonic stem cell medium to investigate the molecular mechanism involved in maintaining a limbal stem cell niche and thus a potentially important clinical application to treat cornean epithelial stem cell loss.
References
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Journal ArticleDOI
Three-dimensional structure of the mammalian limbal stem cell niche.
Kate Grieve,Djida Ghoubay,Cristina Georgeon,Olivier Thouvenin,Nacim Bouheraoua,Michel Paques,Vincent Borderie +6 more
TL;DR: CFE increased with limbal crypt volume and was not significantly decreased in organ-cultured corneoscleral rims, suggesting that stem cells remain protected at the base of crypts during organ culture.
Journal ArticleDOI
Differentiation Potential of Limbal Fibroblasts and Bone Marrow Mesenchymal Stem Cells to Corneal Epithelial Cells
TL;DR: In this paper, the authors aimed at reprogramming stage-specific embryonic antigen-4 (SSEA4+) LFs and BM MSCs into corneal epithelial lineage using a three-dimensional culture system and embryonic stem cell medium.
Journal ArticleDOI
Long-term outcome of iron-endocytosing cultured corneal endothelial cell transplantation with magnetic attraction.
Tatsuya Mimura,Satoru Yamagami,Tomohiko Usui,Yasuo Ishii,Kyoko Ono,Seiich Yokoo,Hideharu Funatsu,Makoto Araie,Shiro Amano +8 more
TL;DR: Corneal findings on slit lamp biomicroscopy, RCEC density, the electro-retinogram (ERG), and residual iron in the ocular tissues were evaluated at final assessment and magnetic attachment of iron-endocytosing CECs can be an effective and safe method for corneal endothelial repair.
Journal ArticleDOI
Donor age and gestational age influence on growth factor levels in human amniotic membrane.
Maria J. López-Valladares,M. Teresa Rodríguez-Ares,Rosario Touriño,Francisco Gude,M. Teresa Silva,José R. Couceiro +5 more
TL;DR: In this paper, the influence of interdonor variations and processing and preservation procedures applied to the amniotic membrane on growth factors and protein levels was investigated, and the authors found that the variability in the biochemical composition of AM from different donors is considerable, and it is related with donor factors as donor age and gestational age.
Journal ArticleDOI
Rapid tissue engineering of biomimetic human corneal limbal crypts with 3D niche architecture.
TL;DR: A method to rapidly and reproducibly create bioengineered limbal crypts (BLCs) in a collagen construct using a simple one-step method that could be applicable to numerous tissue-engineering applications where varied 3-dimensional niche architectures are required.