Journal ArticleDOI
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
Joan Kaufman,Boris Birmaher,David A. Brent,Uma Rao,Uma Rao,Cynthia Flynn,Cynthia Flynn,Paula Moreci,Douglas E. Williamson,Neal D. Ryan +9 more
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TLDR
Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses.Abstract:
Objective To describe the psychometric properties of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL) interview, which surveys additional disorders not assessed in prior K-SADS, contains improved probes and anchor points, includes diagnosis-specific impairment ratings, generates DSM-III-R and DSM-IV diagnoses, and divides symptoms surveyed into a screening interview and five diagnostic supplements. Method Subjects were 55 psychiatric outpatients and 11 normal controls (aged 7 through 17 years). Both parents and children were used as informants. Concurrent validity of the screen criteria and the K-SADS-PL diagnoses was assessed against standard self-report scales. Interrater ( n = 15) and test-retest ( n = 20) reliability data were also collected (mean retest interval: 18 days; range: 2 to 38 days). Results Rating scale data support the concurrent validity of screens and K-SADS-PL diagnoses. Interrater agreement in scoring screens and diagnoses was high (range: 93% to 100%). Test-retest reliability κ coefficients were in the excellent range for present and/or lifetime diagnoses of major depression, any bipolar, generalized anxiety, conduct, and oppositional defiant disorder (.77 to 1.00) and in the good range for present diagnoses of posttraumatic stress disorder and attention-deficit hyperactivity disorder (.63 to .67). Conclusion Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses. J. Am. Acad. Child Adolesc. Psychiatry , 1997, 36(7): 980–988.read more
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Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression.
Shauna MacMillan,Philip R. Szeszko,Gregory J. Moore,Rachel Madden,Elisa Lorch,Jennifer Ivey,S. Preeya Banerjee,David R. Rosenberg +7 more
TL;DR: It is suggested that alterations in amygdala:hippocampal volume ratios in pediatric MDD may more reflect severity of associated anxiety than depression and underscore the importance of assessment for comorbidity in the study of MDD.
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Neural circuitry underlying affective response to peer feedback in adolescence
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Early childhood OCD: preliminary findings from a family-based cognitive-behavioral approach.
Jennifer B. Freeman,Abbe Garcia,Lisa Coyne,Chelsea M. Ale,Amy Przeworski,Michael B. Himle,Scott N. Compton,Henrietta Leonard +7 more
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Sex differences in brain maturation in maltreatment-related pediatric posttraumatic stress disorder.
TL;DR: There are sex differences in the brain maturation of boys and girls with maltreatment-related PTSD, and longitudinal MRI brain investigations of childhood PTSD and the relationship of gender to psychosocial outcomes are warranted.
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Gut microbiome in ADHD and its relation to neural reward anticipation
Esther Aarts,Thomas H. A. Ederveen,Jilly Naaijen,Marcel P. Zwiers,Jos Boekhorst,Harro M. Timmerman,Sanne P. Smeekens,Mihai G. Netea,Jan K. Buitelaar,Barbara Franke,Sacha A. F. T. van Hijum,Alejandro Arias Vasquez +11 more
TL;DR: Increased relative abundance of this functionality was significantly associated with decreased ventral striatal fMRI responses during reward anticipation, independent of ADHD diagnosis and age.
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