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Open AccessJournal ArticleDOI

Sero-epidemiological survey for alveolar echinococcosis (by Em2-ELISA) of blood donors in an endemic area of Switzerland

Bruno Gottstein, +7 more
- 01 Nov 1987 - 
- Vol. 81, Iss: 6, pp 960-964
TLDR
Sera from 17,166 blood donors living in 10 cantons of northern Switzerland in an area endemic for Echinococcus multilocularis were investigated by serological survey for alveolar echinococcosis, finding 2 asymptomatic clinical cases of AE within this population of blood donors.
Abstract: 
Sera from 17 166 blood donors living in 10 cantons of northern Switzerland in an area endemic for Echinococcus multilocularis were investigated by serological survey for alveolar echinococcosis (AE). A highly species-specific antigen (Em2) and a commonly used E. granulosus hydatid fluid antigen (EgHF) were compared for their suitability in seroepidemiology. EgHF showed a degree of nonspecificity which did not allow direct detection of AE cases. Antibody reaction with Em2 resulted in the detection of 2 asymptomatic clinical cases of AE (seroprevalence 0·01%) within this population of blood donors. A further 4 persons were positive in Em2-ELISA. These 4 persons had negative imaging studies and will be followed serologically and clinically.

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Citations
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Journal ArticleDOI

Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern

Johannes Eckert, +1 more
- 01 Jan 2004 - 
TL;DR: Various aspects of human echinococcosis are discussed in this review, including data on the infectivity of genetic variants of E. granulosus to humans, the increasing invasion of cities in Europe and Japan by red foxes, the main definitive hosts ofE.
Book ChapterDOI

Detection, screening and community epidemiology of taeniid cestode zoonoses: cystic echinococcosis, alveolar echinococcosis and neurocysticercosis.

Philip S. Craig, +2 more
- 01 Jan 1996 - 
TL;DR: The chapter addresses the problem of neurocysticercosis and epilepsy in developing countries particularly Latin America and its public health consequences in the USA and elsewhere.
Journal ArticleDOI

Epidemiology of alveolar echinococcosis with particular reference to China and Europe.

Dominique-Angèle Vuitton, +6 more
- 01 Oct 2003 - 
TL;DR: Improved diagnostic technology, as well as a real increase in the infection rate and an extension to new areas, can explain that more than 500 cases of alveolar echinococcosis have been reported for these 2 decades while less than 900 cases were published for the previous 7 decades.
Journal ArticleDOI

An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China

Philip S. Craig, +12 more
- 02 Nov 2000 - 
TL;DR: Long-term transmission of Echinococcus multilocularis and risk of zoonotic infection of south Gansu farmers may be related ultimately to a process of deforestation driven by agriculture and subsequent development of a peri-domestic cycle involving dogs.
Journal ArticleDOI

A large focus of alveolar echinococcosis in central China.

Philip S. Craig, +7 more
- 03 Oct 1992 - 
TL;DR: The high prevalence of human AE in this region of central China is most probably due to semi-domestic transmission of E multilocularis between wild rodents and dogs, together with the poverty and poor hygiene in these rural communities.
References
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Journal ArticleDOI

Chemotherapy for larval echinococcosis in animals and humans: report of a workshop

Peter M. Schantz, +2 more
- 01 Jan 1982 - 
TL;DR: Treatment of human patients infected with E. granulosus is followed by subjective improvement in most, and evidence of regression of cysts in some; in other patients, cysts continue to grow or have been proven viable even after several months of high-dose mebendazole therapy.
Journal ArticleDOI

Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance.

Robert L. Rausch, +3 more
- 01 May 1987 - 
TL;DR: The findings show that the Em2 ELISA may be positive in patients having lesions of AHD in which the etiologic agent is no longer viable, in agreement with the clinical impression that the cestode was dead.
Journal ArticleDOI

Serological differentiation between Echinococcus granulosus and E. multilocularis infections in man.

Bruno Gottstein, +2 more
- 01 Jan 1983 - 
TL;DR: An enzyme-linked immunosorbent assay (ELISA) was adapted for the serological differential diagnosis of cystic or alveolar echinococcosis in man caused by Echinococcus granulosus or E. multilocularis respectively.
Journal ArticleDOI

Purification and characterization of a specific antigen from Echinococcus multilocularis.

Bruno Gottstein
- 01 May 1985 - 
TL;DR: A polypeptide (Em2a) purified by affinity chromatography from the Echinococcus multilocularis metacestode showed a high degree of purity as assayed by SDS‐PAGE and analytical isoelectrical focusing and a minor contamination with host albumin was revealed.
Journal ArticleDOI

Determination of parasite-specific immunoglobulins using the ELISA in patients with echinococcosis treated with mebendazole

Bruno Gottstein, +2 more
- 01 Jan 1984 - 
TL;DR: Parasite-specific immunoglobulin classes were determined by the ELISA in sera of 19 patients with cystic or alveolar echinococcosis before and after 2 years of continuous treatment with mebendazole at daily doses of 35–50 mg/kg body weight.
Related Papers (5)

Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance.

Robert L. Rausch, +3 more
- 01 May 1987 - 

Serological differentiation between Echinococcus granulosus and E. multilocularis infections in man.

Bruno Gottstein, +2 more
- 01 Jan 1983 - 

Seroepidemiologic screening of Echinococcus multilocularis infection in a European area endemic for alveolar echinococcosis

Solange Bresson-Hadni, +9 more
- 01 Dec 1994 - 

Improved primary immunodiagnosis of alveolar echinococcosis in humans by an enzyme-linked immunosorbent assay using the Em2plus antigen.

Bruno Gottstein, +3 more
- 01 Feb 1993 - 

Purification and characterization of a specific antigen from Echinococcus multilocularis.

Bruno Gottstein
- 01 May 1985 - 
Frequently Asked Questions (1)
Q1. What are the contributions in "Sero-epidemiological survey for alveolar echinococcosis (by em2-elisa) of blood donors in an endemic area of switzerland" ?

Gottstein et al. this paper compared a highly species-specific antigen ( Em2 ) and a commonly used E. granulosus hydatid fluid antigen ( EgHF ) for their suitability in seroepidemiology.