The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
TLDR
This work discusses knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system and some of the SCN output pathways serve as input pathways for peripheral tissues.Abstract:
Most physiology and behavior of mammalian organisms follow daily oscillations. These rhythmic processes are governed by environmental cues (e.g., fluctuations in light intensity and temperature), an internal circadian timing system, and the interaction between this timekeeping system and environmental signals. In mammals, the circadian timekeeping system has a complex architecture, composed of a central pacemaker in the brain's suprachiasmatic nuclei (SCN) and subsidiary clocks in nearly every body cell. The central clock is synchronized to geophysical time mainly via photic cues perceived by the retina and transmitted by electrical signals to SCN neurons. In turn, the SCN influences circadian physiology and behavior via neuronal and humoral cues and via the synchronization of local oscillators that are operative in the cells of most organs and tissues. Thus, some of the SCN output pathways serve as input pathways for peripheral tissues. Here we discuss knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system.read more
Citations
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Central and Peripheral Circadian Clocks in Mammals
TL;DR: An emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.
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Transcriptional architecture of the mammalian circadian clock
TL;DR: Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling.
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Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
TL;DR: The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision.
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Molecular architecture of the mammalian circadian clock.
TL;DR: Recent advances in understanding of the core molecular clock are highlighted and how it utilizes diverse transcriptional and post-transcriptional mechanisms to impart temporal control onto mammalian physiology is highlighted.
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Circadian typology: a comprehensive review.
Ana Adan,Simon Archer,Maria Paz Loayza Hidalgo,Lee Di Milia,Vincenzo Natale,Christoph Randler +5 more
TL;DR: This review of the psychometric properties and validity of CT measures as well as individual, environmental and genetic factors that influence the circadian typology provides a state of the art discussion to allow professionals to integrate chronobiological aspects of human behavior into their daily practice.
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