Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics*
Rosane Orofino-Costa,Priscila Marques de Macedo,Anderson Messias Rodrigues,Andréa Reis Bernardes-Engemann +3 more
TLDR
The serological and molecular techniques are used as an auxiliary tool for the diagnosis and/or for species identification, although the isolation and the identification of Sporothrix spp.Abstract:
In the late 90's there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. In addition to becoming hyperendemic, uncommon clinical pictures like immunoreactive clinical presentations or severe systemic cases have emerged. New species were identified and classified through molecular tools using more virulent clinical isolates, like S. brasiliensis, compared to the environmental isolates. Likewise, different species of Sporothrix have been associated with different geographic regions. The serological and molecular techniques are used as an auxiliary tool for the diagnosis and/or for species identification, although the isolation and the identification of Sporothrix spp. in clinical specimen is still the gold standard. Currently sporotrichosis epidemics requires the knowledge of the epidemiological-molecular profile to control the disease and the specific treatment. Itraconazole, potassium iodide, terfinafine, and amphotericin B are the available drugs in Brazil to treat sporotrichosis. The drug of choice, its posology, and treatment duration vary according to the clinical presentation, the Sporothrix species, and host immune status. New treatment choices, including a vaccine, are being developed; nevertheless, more clinical trials are required to confirm its efficacy.read more
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The threat of emerging and re-emerging pathogenic Sporothrix species
Anderson Messias Rodrigues,Paula Portella Della Terra,Isabella Dib Ferreira Gremião,Sandro Antonio Pereira,Rosane Orofino-Costa,Zoilo Pires de Camargo +5 more
TL;DR: In this article, the authors discuss the main features of the expanding epidemics driven by S. brasiliensis in cats and humans, which contributed to the definition of new paradigms in Sporothrix transmission, reaching epidemic levels, making the disease a serious public health problem.
Journal ArticleDOI
Sporotrichosis In Immunocompromised Hosts.
TL;DR: This work reviewed the main epidemiologic, clinical, diagnostic and therapeutic aspects of sporotrichosis in immunocompromised hosts, which may be associated with rather more severe clinical courses, larger fungal burden and longer periods of systemic antifungal therapy.
Journal ArticleDOI
A One Health Approach to Combatting Sporothrix brasiliensis: Narrative Review of an Emerging Zoonotic Fungal Pathogen in South America
John Rossow,Flavio Queiroz-Telles,Diego H. Cáceres,Karlyn D. Beer,Brendan R Jackson,Jose Guillermo Pereira,Isabella Dib Ferreira Gremião,Sandro Antonio Pereira +7 more
TL;DR: Cat-transmitted sporotrichosis caused by Sporothrix brasiliensis has become a major public health concern and presents a distinct divergence from the traditional epidemiology of sporot richosis.
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Sporotrichosis caused by Sporothrix brasiliensis in Argentina: Case report, molecular identification and in vitro susceptibility pattern to antifungal drugs
Alejandro Etchecopaz,N. Lanza,María Agustina Toscanini,Tomás Brito Devoto,S. Pola,Gabriela López Daneri,C. Iovannitti,María Luján Cuestas +7 more
TL;DR: This study contributed to the molecular epidemiology of Sporothrix species in Argentina and the characterization of the in vitro susceptibility pattern of S. brasiliensis isolates recovered from a cat and two humans involved in this case of zoonotic sporotrichosis.
Journal ArticleDOI
Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision
Isabella Dib Ferreira Gremião,Elisabeth Martins da Silva da Rocha,Hildebrando Montenegro,Aroldo José Borges Carneiro,Melissa Orzechowski Xavier,Marconi Rodrigues de Farias,Fabiana dos Santos Monti,Wilson Mansho,Romeika Herminia de Macedo Assunção Pereira,Sandro Antonio Pereira,Leila M. Lopes-Bezerra +10 more
TL;DR: A Brazilian guideline for the management of feline sporotrichosis, a mycosis caused by Sporothrix brasiliensis, which intends to provide information on clinical-epidemiological aspects of this zoonosis, as well as a literature revision.
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Journal ArticleDOI
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