Journal ArticleDOI
Spotlight on S-ICD™ therapy: 10 years of clinical experience and innovation.
Nils Bögeholz,Kevin Willy,Philipp Niehues,Benjamin Rath,Dirk G. Dechering,Gerrit Frommeyer,Simon Kochhäuser,A. Löher,Julia Köbe,Florian Reinke,Lars Eckardt +10 more
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TLDR
The S-ICD™ performance is promising even for many patients, who may not be 'classical' candidates for this technology, which sheds a spotlight on S- ICD™ therapy in recently discovered fields of indication beyond ideal preconditions.Abstract:
Subcutaneous ICD (S-ICD™) therapy has been established in initial clinical trials and current international guideline recommendations for patients without demand for pacing, cardiac resynchronization, or antitachycardia pacing. The promising experience in 'ideal' S-ICD™ candidates increasingly encourages physicians to provide the benefits of S-ICD™ therapy to patients in clinical constellations beyond 'classical' indications of S-ICD™ therapy, which has led to a broadening of S-ICD™ indications in many centres. However, the decision for S-ICD™ implantation is still not covered by controlled randomized trials but rather relies on patient series or observational studies. Thus, this review intends to give a contemporary update on available empirical evidence data and technical advancements of S-ICD™ technology and sheds a spotlight on S-ICD™ therapy in recently discovered fields of indication beyond ideal preconditions. We discuss the eligibility for S-ICD™ therapy in Brugada syndrome as an example for an adverse and dynamic electrocardiographic pattern that challenges the S-ICD™ sensing and detection algorithms. Besides, the S-ICD™ performance and defibrillation efficacy in conditions of adverse structural remodelling as exemplified for hypertrophic cardiomyopathy is discussed. In addition, we review recent data on potential device interactions between S-ICD™ systems and other implantable cardio-active systems (e.g. pacemakers) including specific recommendations, how these could be prevented. Finally, we evaluate limitations of S-ICD™ therapy in adverse patient constitutions, like distinct obesity, and present contemporary strategies to assure proper S-ICD™ performance in these patients. Overall, the S-ICD™ performance is promising even for many patients, who may not be 'classical' candidates for this technology.read more
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Journal ArticleDOI
Evaluation of subcutaneous implantable cardioverter-defibrillator performance in patients with ion channelopathies from the EFFORTLESS cohort and comparison with a meta-analysis of transvenous ICD outcomes.
Pier D. Lambiase,Lars Eckardt,Dominic A.M.J. Theuns,Timothy R. Betts,Andreas L. Kyriacou,Elizabeth Duffy,Reinoud E. Knops +6 more
TL;DR: EFFORTLESS demonstrates similar S-ICD efficacy and a nonsignificant, lower rate of IAS in channelopathy patients as compared to structural heart disease and Comparable IAS rates were achieved with the device programmed to higher rates forChannelopathy patients.
Journal ArticleDOI
Der tragbare Kardioverter/Defibrillator (WCD) – Indikationen und Einsatz
T. Deneke,Ralph Bosch,Lars Eckardt,Bernd Nowak,J. O. Schwab,Philipp Sommer,C. Veltmann,Thomas M. Helms +7 more
TL;DR: In der kürzlich publizierten randomisierten VEST-Studie zeigte sich, bei allerdings geringer Therapieadhärenz, kein Vorteil des WCD hinsichtlich der Verhinderung des plötzlichen Herztodes dokumentiert werden.
Journal ArticleDOI
Clinical experience regarding safety and diagnostic value of cardiovascular magnetic resonance in patients with a subcutaneous implanted cardioverter/defibrillator (S-ICD) at 1.5 T.
Viktoria Holtstiege,Claudia Meier,Michael Bietenbeck,Grigorios Chatzantonis,Anca Florian,Julia Köbe,Florian Reinke,Lars Eckardt,Ali Yilmaz +8 more
TL;DR: Safe 1.5 T CMR studies should not be withhold in patients with S-ICD for safety concerns and/or fear of extensive imaging artefacts precluding successful image analysis, according to the present study.
Journal ArticleDOI
Brugada syndrome: Eligibility for subcutaneous implantable cardioverter-defibrillator after exercise stress test
Pedro von Hafe,Bebiana Faria,Geraldo Dias,Filipa Cardoso,Maria José Alves,Assunção Alves,Bernardete Rodrigues,Sílvia Ribeiro,Victor Sanfins,António Lourenço +9 more
TL;DR: In this paper, the authors test electrocardiographic eligibility for S-ICD placement after exercise stress testing (EST) in patients with Brugada syndrome (BrS) using the Boston Scientific model 2889 EMBLEM™ automated screening tool.
Journal ArticleDOI
The subcutaneous ICD for prevention of sudden cardiac death: Current evidence and future directions.
TL;DR: It is suggested that current generation S‐ICD systems may be a valid alternative in patients with an ICD indication in whom bradycardia pacing or cardiac resynchronization therapy is not required due to a lower risk of system‐related problems.
References
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2015 ESC Guidelines for the Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death.
Silvia G. Priori,Carina Blomström-Lundqvist,Andrea Mazzanti,Nico A. Blom,Martin Borggrefe,John Camm,Perry M. Elliott,Donna Fitzsimons,Robert Hatala,Gerhard Hindricks,Paulus Kirchhof,Keld Kjeldsen,Karl Heinz Kuck,Antonio Hernández-Madrid,Nikolaos Nikolaou,Tone M. Norekvål,Christian Spaulding,Dirk J. van Veldhuisen +17 more
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2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC).
Silvia G. Priori,Carina Blomström-Lundqvist,Andrea Mazzanti,Nico A. Blom,Martin Borggrefe,John Camm,Perry M. Elliott,Donna Fitzsimons,Robert Hatala,Gerhard Hindricks,Paulus Kirchhof,Keld Kjeldsen,Karl-Heinz Kuck,Antonio Hernández-Madrid,Nikolaos Nikolaou,Tone M. Norekvål,Christian Spaulding,Dirk J. van Veldhuisen +17 more
TL;DR: In this article, the authors proposed AMIOdarone versus implantable cardioverter-defibrillator (ICD-DV) for the treatment of atrial fibrillation.
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HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)
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Journal ArticleDOI
HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies
Michael J. Ackerman,Silvia G. Priori,Stephan Willems,Charles I. Berul,Ramon Brugada,Hugh Calkins,A. John Camm,Patrick T. Ellinor,Michael H. Gollob,Robert Hamilton,Ray E. Hershberger,Daniel P. Judge,Daniel P. Judge,Hervé Le Marec,William J. McKenna,Eric Schulze-Bahr,Christopher Semsarian,Jeffrey A. Towbin,Hugh Watkins,Arthur A.M. Wilde,Christian Wolpert,Douglas P. Zipes +21 more
TL;DR: This international consensus statement provides the state of genetic testing for the channelopathy and cardiomyopathies and summarizes the opinion of the international writing group members based on their own experience and on a general review of the literature with respect to the use and role of geneticTesting for these potentially heritable cardiac conditions.
Journal ArticleDOI
2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death
Silvia G. Priori,Carina Blomström-Lundqvist,Andrea Mazzanti,Nico A. Blom,Martin Borggrefe,John Camm,Perry M. Elliott,Donna Fitzsimons,Robert Hatala,Gerhard Hindricks,Paulus Kirchhof,Keld Kjeldsen,Karl Heinz Kuck,Antonio Hernández-Madrid,Nikolaos Nikolaou,Tone M. Norekvål,Christian Spaulding,Dirk J. van Veldhuisen +17 more
TL;DR: Authors/Task Force Members: Silvia G. Priori (Chairperson), Carina Blomström-Lundqvist (Co-chairperson) (Sweden), Andrea Mazzanti† (Italy), Nico Blom (The Netherlands), Martin Borggrefe (Germany), John Camm (UK), Perry Mark Elliott (UK).