Journal ArticleDOI
Sterol metabolism. VII. Autoxidation of cholesterol via hydroperoxide intermediates
Reads0
Chats0
About:
This article is published in Journal of Organic Chemistry.The article was published on 1970-08-01. It has received 101 citations till now. The article focuses on the topics: Autoxidation.read more
Citations
More filters
Journal ArticleDOI
Chemiluminescent determination of cholesterol hydroperoxides in human erythrocyte membrane
TL;DR: Analysis of erythrocyte membranes from seven healthy volunteers identified Ch 7α-OOH and Ch 7β-OOh, but not Ch 5α-ooH, as commonly occurring components.
Journal ArticleDOI
Studies on the Biosynthetic Conversion of Cholesterol into Pregnenolone: SIDE CHAIN CLEAVAGE OF SOME 20-p-TOLYL ANALOGS OF CHOLESTEROL AND 20α-HYDROXYCHOLESTEROL
TL;DR: The results support the previously advanced hypothesis that the true intermediates in the side chain cleavage of cholesterol are reactive complexes of a metalloenzyme and oxygenated steroidal species, and not free hydroxylated compounds.
Journal ArticleDOI
Steroid hydroperoxides as substrates for glutathione peroxidase.
TL;DR: Cholesterol 25-hydroperoxide would not function as a substrate and is the first hydroperoxide so far reported that cannot be metabolized by glutathione peroxidase.
Journal ArticleDOI
Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450scc
Seymour Lieberman,Yong Yeng Lin +1 more
TL;DR: In this paper, the authors examined the evidence upon which the presently accepted version of the mechanism of the cytochrome P450(scc)-catalyzed cleavage of the sidechain of cholesterol is based.
Journal ArticleDOI
Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key
Philippe Liere,Antoine Pianos,Bernard Eychenne,Annie Cambourg,Karl Bodin,William J. Griffiths,Michael Schumacher,Etienne-Emile Baulieu,Jan Sjövall +8 more
TL;DR: This study shows that an early removal of CHOL from brain extracts coupled to well-validated extraction and fractionation procedures are prerequisites for reliable measurements of free and conjugated PREG and DHEA by GC-MS or other indirect methods.