Journal ArticleDOI
Structural advances for the major facilitator superfamily (MFS) transporters
TLDR
This review discusses recent progress in MFS structure analysis and focuses on the molecular basis for substrate binding, co-transport coupling, and alternating access.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2013-03-01. It has received 329 citations till now. The article focuses on the topics: Major facilitator superfamily.read more
Citations
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Journal ArticleDOI
Crystal structure of the human glucose transporter GLUT1
TL;DR: Structural comparison of the uniporter GLUT1 with its bacterial homologue XylE, a proton-coupled xylose symporter, allows examination of the transport mechanisms of both passive facilitators and active transporters.
Journal ArticleDOI
Shared Molecular Mechanisms of Membrane Transporters
David A. Drew,Olga Boudker +1 more
TL;DR: This review compares and contrast rocker-switch, rocking-bundle, and elevator alternating-access mechanisms to highlight shared features and novel refinements to the basic alternating- access model.
Journal ArticleDOI
Structural Biology of the Major Facilitator Superfamily Transporters.
TL;DR: The history, classification, and general features of the MFS proteins are reviewed; recent structural progress is summarized with a focus on the sugar porter family transporters exemplified by GLUT1; and the molecular mechanisms of substrate binding, alternating access, and cotransport coupling are discussed.
Journal ArticleDOI
Understanding transport by the major facilitator superfamily (MFS): structures pave the way
TL;DR: An updated model for the conformational cycle of MFS transporters, the 'clamp-and-switch model', is proposed and the role of so-called 'gating residues' and the substrate in modulating these conformational changes are discussed.
Journal ArticleDOI
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes
TL;DR: This review focuses on studies published over the past decade that have provided much insight into the mechanisms of the enzymes that carry out the post-translational modifications of lanthipeptides.
References
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Book
Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
Journal Article
The major facilitator superfamily.
Milton H. Saier,Beatty Jt,André Goffeau,Kevin T. Harley,Wilbert H.M. Heijne,Huang Sc,Donald L. Jack,Jähn Ps,Lew K,Jun Liu,Stephanie S. Pao,Ian T. Paulsen,Tsai-Tien Tseng,Virk Ps +13 more
TL;DR: Evidence is presented substantiating the proposal that an internal tandem gene duplication event gave rise to a primordial MFS protein before divergence of the family members.
Journal ArticleDOI
Major Facilitator Superfamily
TL;DR: The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth as discussed by the authors, and all homologous MFS protein sequences in the public databases as of January 1997 were identified on the basis of sequence similarity.
Journal ArticleDOI
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Søren G. F. Rasmussen,Hee Jung Choi,Juan Jose Fung,Els Pardon,Paola Casarosa,Pil Seok Chae,Brian T. DeVree,Daniel M. Rosenbaum,Foon Sun Thian,Tong Sun Kobilka,Andreas Schnapp,Ingo Konetzki,Roger K. Sunahara,Samuel H. Gellman,Alexander Pautsch,Jan Steyaert,William I. Weis,Brian K. Kobilka +17 more
TL;DR: A camelid antibody fragment to the human β2 adrenergic receptor is generated, and an agonist-bound, active-state crystal structure of the receptor-nanobody complex is obtained, providing insights into the process of agonist binding and activation.
Journal ArticleDOI
Functional roles for noise in genetic circuits
Avigdor Eldar,Michael B. Elowitz +1 more
TL;DR: Examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables are reviewed.