Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors
Nan Chiang,Charles N. Serhan +1 more
TLDR
It is suggested that it is time to develop immunoresolvents as agonists for testing resolution pharmacology in nutrition and health as well as in human diseases and during surgery.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2017-12-01 and is currently open access. It has received 240 citations till now.read more
Citations
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Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.
Charles N. Serhan,Bruce D. Levy +1 more
TL;DR: This Review focuses on the resolution phase of inflammation with identification of specialized pro-resolving mediators (SPMs) that involve three separate biosynthetic and potent mediator families, which are defined using the first quantitative resolution indices to score this vital process.
Journal ArticleDOI
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids
TL;DR: The role that is played by the TLR4 signaling pathway in the inflammatory response and its modulation by saturated and omega-3 polyunsaturated fatty acids is described.
Journal ArticleDOI
The role of inflammation in the development of epilepsy
Amna Z Rana,Alberto E. Musto +1 more
TL;DR: Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.
Journal ArticleDOI
Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
TL;DR: This review summarizes current knowledge on the involvement of the main classes of endogenous bioactive lipids—namely classical eicosanoids, pro-resolving lipid mediators, lysoglycerophospholipid/sphingolipids, and endocannabinoids—in the cellular and molecular mechanisms that lead to the pathogenesis of chronic disorders.
Journal ArticleDOI
Nutrition, immunity and COVID-19.
TL;DR: It would seem prudent for individuals to consume sufficient amounts of essential nutrients to support their immune system to help them deal with pathogens should they become infected.
References
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Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
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Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
TL;DR: Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions.
Journal ArticleDOI
Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
Journal ArticleDOI
Pro-resolving lipid mediators are leads for resolution physiology
TL;DR: The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.
Journal ArticleDOI
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
Charles N. Serhan,Song Hong,Karsten Gronert,Sean P. Colgan,Pallavi R. Devchand,Gudrun E. Mirick,Rose-Laure Moussignac +6 more
TL;DR: It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid produce a novel family of bioactive 17R-hydroxy-containing di- and tri-Hydroxy-docosanoids termed resolvins.
Related Papers (5)
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.
Charles N. Serhan,Bruce D. Levy +1 more