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Structure-affinity relationship of dietary anthocyanin-HSA interaction

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TLDR
The bioavailability of anthocyanins is the key factor influencing their health benefits as mentioned in this paper, and the bioavailability is the most important factor influencing the health benefits of the plant pigments.
Abstract
BACKGROUND: Dietary anthocyanins are plant pigments which occur with different chemical structures, being widely present in fruits and in many vegetables, are claimed to be beneficial for human health. The bioavailability of anthocyanins is the key factor influencing their health benefits.

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Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes.

TL;DR: This review will try to present exclusive study on phenolics with its mode of action mitigating liver associated complications and also its future prospects as new drug lead.
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Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.

TL;DR: The protein binding rates of structurally different flavonoids to human serum albumin (HSA) were elucidated by applying the high performance affinity chromatography (HPAC) and it was found that an additional methoxy group in flavone ring A would decrease the protein binding rate.
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Anti-diabetic effects of natural antioxidants from fruits

TL;DR: Fruits are good resources of anti-di diabetic nutrients and a balanced diet rich in different fruits is recommended for diabetic patients and the pre-diabetic population.
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Protection of cyanidin-3-O-glucoside against acrylamide- and glycidamide-induced reproductive toxicity in leydig cells

TL;DR: It was concluded that C3G is effective in reducing AA- and GA-induced reproductive toxicity via inhibition of ROS generation, mitochondrial membrane depolarization and apoptosis, as well as activating steroidogenic enzymes.
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Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions

TL;DR: To avoid the side effects arising from changes in plasma protein binding, the intake of flavonoid-rich food and beverages should be taken into consideration when treating certain pathologies.
References
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Journal ArticleDOI

Analysis and biological activities of anthocyanins.

TL;DR: This article reviews their biological functions and pre-clinical studies, as well as the most recent analytical techniques concerning anthocyanin isolation and identification.
Journal ArticleDOI

The bioavailability and absorption of anthocyanins : Towards a better understanding

TL;DR: This review attempts to summarize some aspects of anthocyanin biochemistry and discusses these in the context of what is currently known about bioavailability and absorption in relation to flavonoid groups.
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Dietary flavonoid aglycones and their glycosides: Which show better biological significance?

TL;DR: With in vivo (oral) treatment, flavonoids glycosides showed similar or even higher antidiabetes, anti-inflammatory, antidegranulating, antistress, and antiallergic activity than their flavonoid aglycones.
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The stomach as a site for anthocyanins absorption from food1

TL;DR: The ability of grape anthocyanins to permeate the gastric mucosa can be suggested as a possible explanation of the fast kinetics of plasma appearance of anthocaranins in rats and humans as mentioned in this paper.
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Health benefits of anthocyanins and molecular mechanisms: Update from recent decade

TL;DR: This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms and suggests that several signaling pathways are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future.
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