Structure and Promoter Analysis of Math3 Gene, a Mouse Homolog of Drosophila Proneural Geneatonal NEURAL-SPECIFIC EXPRESSION BY DUAL PROMOTER ELEMENTS
TLDR
Results indicate that Math3 promoter contains two essential regulatory regions, the proximal 193-base pair region, which confers efficient neural-specific expression, and a region further upstream, required for retinal expression.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-03-13 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Upstream activating sequence & TATA box.read more
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Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.
Toshiyuki Ohtsuka,Makoto Ishibashi,Makoto Ishibashi,Gerald Gradwohl,Shigetada Nakanishi,François Guillemot,Ryoichiro Kageyama +6 more
TL;DR: It is demonstrated that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation in neural precursor cells prepared from wild‐type, Hes1‐null, Hes5‐null and Hes1-Hes5 double‐null mouse embryos.
Journal ArticleDOI
Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system.
Koichi Tomita,Koki Moriyoshi,Koki Moriyoshi,Shigetada Nakanishi,François Guillemot,Ryoichiro Kageyama +5 more
TL;DR: Results indicated that Mash1 and Math3 direct neuronal versus glial fate determination in the CNS and raised the possibility that downregulation of these bHLH genes is one of the mechanisms to initiate gliogenesis.
Journal ArticleDOI
The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation
TL;DR: Mutation analysis revealed that Hes1- and Hes6-specific functions are, at least in part, interchangeable by alteration of the loop region, suggesting that the loop is not simply a nonfunctional spacer but plays an important role in the specific functions.
Journal ArticleDOI
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina
Masato Hojo,Toshiyuki Ohtsuka,Nobuo Hashimoto,Gerald Gradwohl,Francois Guillemot,Ryoichiro Kageyama +5 more
TL;DR: It is found that, in mouse retina, the bHLH gene Hes5 was specifically expressed by differentiating Müller glial cells and that misexpression of Hes5 with recombinant retrovirus significantly increased the population ofglial cells at the expense of neurons.
Journal ArticleDOI
Roles of homeobox and bHLH genes in specification of a retinal cell type.
TL;DR: It is found that in Mash1-Math3 double-mutant retina, which exhibits a complete loss of bipolar cells, Chx10 expression did not disappear but remained in Müller glial cells, suggesting that Chx8 expression per se is compatible with gliogenesis, and the bHLH genes may be involved in neuronal subtype specification.
References
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Journal Article
Improved Retroviral Vectors for Gene Transfer and Expression
A D Miller,G J Rosman +1 more
TL;DR: A set of murine retrovirus-based vectors that include unique cloning sites for insertion of cDNAs such that the cDNA can be driven by either the retroviral long terminal repeat, the immediate early promoter of human cytomegalovirus, or the simian virus 40 early promoter are described.
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Signalling downstream of activated mammalian Notch.
Sophie Jarriault,Christel Brou,Frédérique Logeat,Eric H. Schroeter,Raphael Kopan,Alain Israël +5 more
TL;DR: It is shown that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-JK and act as transcriptional activators through theKBF2-binding sites of the HES-1 promoter and block MyoD-induced myogenesis5-7.
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A common progenitor for neurons and glia persists in rat retina late in development
TL;DR: Retrovirus-mediated gene transfer was used to mark cell lineages in vivo in the postnatal rat retina, indicating that a single retinal progenitor can generate remarkably diverse cell types near the end of development.
Journal ArticleDOI
Mouse small eye results from mutations in a paired-like homeobox-containing gene.
Robert E. Hill,Jack Favor,Brigid L.M. Hogan,Carl C. T. Ton,Grady F. Saunders,Isabel M. Hanson,Jane Prosser,Tim Jordan,Nicholas D. Hastie,Veronica van Heyningen +9 more
TL;DR: Analysis of three independent Sey alleles is reported and it is shown that indeed this gene is mutated and that the mutations would predictably interrupt gene function.
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Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
Jacqueline E. Lee,Stanley M. Hollenberg,Stanley M. Hollenberg,Lauren Snider,Lauren Snider,David L. Turner,Naomi Lipnick,Harold Weintraub,Harold Weintraub +8 more
TL;DR: The data suggest that neuroD may participate in the terminal differentiation step during vertebrate neuronal development and seems competent to bypass the normal inhibitory influences that usually prevent neurogenesis in ventral and lateral ectoderm.