Journal ArticleDOI
Studies of chemical exchange by nuclear magnetic relaxation in the rotating frame
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In this article, the exchange of protons between sites with different chemical shift is studied by means of N.M. relaxation time measurements (T 1ρ ) in the presence of an r.f. magnetic field.Abstract:
The exchange of protons between sites with different chemical shift is studied by means of N.M.R. relaxation time measurements (T 1ρ ) in the presence of an r.f. magnetic field. The system studied is chair-to-chair isomerization in cyclohexane. The exchange rate and chemical shift are measured in the temperature range 215°k to 250°k. The method is compared with other N.M.R. techniques for studying chemical exchange and is found to have advantages particularly at high exchange rates.read more
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Book ChapterDOI
Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules.
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Mapping of Spectral Density Functions Using Heteronuclear NMR Relaxation Measurements
TL;DR: In this article, the authors measured the transverse relaxation times of in-phase coherence, T,( N,,Y), and of antiphase coherence for the heteronucleus N. The proposed approach has the advantage that it does not rely on any a priori model assumptions about the shape of J(w).
Journal ArticleDOI
Structure of an Intermediate State in Protein Folding and Aggregation
Philipp Neudecker,Paul Robustelli,Andrea Cavalli,Patrick Walsh,Patrik Lundström,Arash Zarrine-Afsar,Simon Sharpe,Michele Vendruscolo,Lewis E. Kay +8 more
TL;DR: The structure provides a detailed characterization of the non-native interactions stabilizing an aggregation-prone intermediate under native conditions and insight into how such an intermediate can derail folding and initiate fibrillation.
References
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Journal ArticleDOI
Study of Moderately Rapid Chemical Exchange Reactions by Means of Nuclear Magnetic Double Resonance
Sture Forsén,Ragnar A. Hoffman +1 more
TL;DR: In this paper, a nuclear magnetic double resonance method for the determination of chemical exchange rates has been developed, which is applicable to systems in which a nuclear spin is reversibly transferred between two nonequivalent sites, A and B, and is obtained through the study of the decay to a new equilibrium value of Signal A upon the sudden saturation of Signal B.
Journal ArticleDOI
Nuclear magnetic resonance study of the proton transfer in water
TL;DR: In this paper, the authors measured the nuclear relaxation in water and showed that the increase of relaxation rate is observable in natural water (0.037% O17), and becomes very appreciable in water enriched in O17.
Journal ArticleDOI
Nuclear magnetic resonance methods for determining chemical-exchange rates.
Journal ArticleDOI
Nuclear Magnetic Dipole—Dipole Relaxation Along the Static and Rotating Magnetic Fields: Application to Gypsum
David C. Look,Irving J. Lowe +1 more
TL;DR: In this paper, general formulas are derived for the spin lattice relaxation times along the static magnetic field (T1) and the rotating field(T1r) due to magnetic dipole-dipole interactions.
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