Journal ArticleDOI
Studies of insulin, growth hormone and prolactin binding: ontogenesis, effects of sex and pregnancy.
TLDR
The ontogenesis of specific binding of 125I-labeled insulin, hGH and oPRL was measured in tissues from rat, rabbit and guinea pig and three patterns of125I-insulin binding with respect to development were observed.Abstract:
The ontogenesis of specific binding of 125I-labeled insulin, hGH and oPRL was measured in tissues from rat, rabbit and guinea pig. Binding of 125I-oPRL and 125I-hGH was very low in liver membranes from fetal and immature rats. A 9- fold (oPRL) and 3.5-fold (hGH) increase in binding occurred between 20 and 40 days of age with a greater increase in binding in mid and late pregnancy. Binding to male liver membranes was significantly lower at all stages of development. There were no significant changes in the binding of 125I-hGH from fetal through 30 day rabbit liver membranes. Between 30 and 60 days of age, a 6-fold increase in binding occurred, with a further increase in binding during pregnancy. A similar overall pattern was observed with I25I-bGH. The increase in specific binding of 125I-oPRL was more gradual and occurred earlier than for 125I-GH. In the guinea pig, three patterns of 125I-insulin binding with respect to development were observed. Fetal placenta and kidney showed marked increase in specifi...read more
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Journal ArticleDOI
Partitioning of Nutrients During Pregnancy and Lactation: A Review of Mechanisms Involving Homeostasis and Homeorhesis
Dale E. Bauman,W. B. Currie +1 more
TL;DR: While not definitively established, roles for placental lactogen and prolactin are attractive possibilities in homeorhetic regulation of maternal tissues to support pregnancy and the initiation of lactaion, respectively.
Journal ArticleDOI
Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family
Jean-Marie Boutin,Christine Jolicoeur,Hiroaki Okamura,Jean Gagnon,Marc Edery,Mariko Shirota,Denis Banville,Isabelle Dusanter-Fourt,Jean Djiane,Paul A. Kelly +9 more
TL;DR: There is strong localized sequence identity between these two receptors in both the extracellular and cytoplasmic domains, suggesting that the two receptors originated from a common ancestor.
Journal ArticleDOI
Mammary gland neoplasia in long-term rodent studies
Irma H. Russo,Jose Russo +1 more
TL;DR: Until there is enough information on the predictive value of mechanism-based toxicology for risk assessment, this approach should be used in conjunction with and validated by the traditional in vivo long-term bioassays, combined with comparative in vitro systems.
Journal ArticleDOI
Role of hormones in mammary cancer initiation and progression.
Irma H. Russo,Jose Russo +1 more
TL;DR: It is still unclear whether estrogens arecarcinogenicity of estrogens to the human breast, but in experimental animal models estrogens can induce mammary cancer.
Journal ArticleDOI
Prolactin receptors in rat liver: possible induction by prolactin.
TL;DR: The observations suggest that prolactin induces its own receptor, and the increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating Prolactin.