Study on the interaction between active components from traditional Chinese medicine and plasma proteins
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TLDR
This review summarizes the common analytical methods used to study the active herbal components-protein binding and gives the examples to illustrate their application and rules and influence factors of the binding between different types of active herbal component and plasma proteins.Abstract:
Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand years. Active components in Chinese herbal medicine are the material basis for the prevention and treatment of diseases. Research on drug-protein binding is one of the important contents in the study of early stage clinical pharmacokinetics of drugs. Plasma protein binding study has far-reaching influence on the pharmacokinetics and pharmacodynamics of drugs and helps to understand the basic rule of drug effects. It is important to study the binding characteristics of the active components in Chinese herbal medicine with plasma proteins for the medical science and modernization of TCM. This review summarizes the common analytical methods which are used to study the active herbal components-protein binding and gives the examples to illustrate their application. Rules and influence factors of the binding between different types of active herbal components and plasma proteins are summarized in the end. Finally, a suggestion on choosing the suitable technique for different types of active herbal components is provided, and the prospect of the drug-protein binding used in the area of TCM research is also discussed.read more
Citations
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A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine.
Haiyu Xu,Yanqiong Zhang,Ping Wang,Junhong Zhang,Hong Chen,Luoqi Zhang,Xia Du,Chunhui Zhao,Dan Wu,Feng Liu,Hongjun Yang,Changxiao Liu +11 more
TL;DR: This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP, an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics–pharmacodynamics correlations.
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The dipeptidyl peptidase-4 inhibitory effect of flavonoids is hindered in protein rich environments.
Carina Proença,Marisa Freitas,Daniela Ribeiro,Sara M. Tomé,Alberto N. Araújo,Artur M. S. Silva,Pedro A. Fernandes,Eduarda Fernandes +7 more
TL;DR: The obtained results showed that the inhibitory effect of flavonoids against DPP-4 was hindered in protein rich environments, like that occurring in blood, and indicated the need for experimental refinement in drug discovery for blood targets.
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Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors.
Lucile Lecas,Lucie Hartmann,Lydia N. Caro,Sarah Mohamed-Bouteben,Claire Raingeval,Isabelle Krimm,Renaud Wagner,Vincent Dugas,Claire Demesmay +8 more
TL;DR: It is shown for the first time that lipid-nanodisc systems (membrane-mimicking environment) and miniaturized affinity chromatography can be combined to identify specific small molecule ligands that bind to an integral membrane protein.
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Potential and applications of capillary electrophoresis for analyzing traditional Chinese medicine: a critical review.
TL;DR: In this article, a review of the use of electrophoresis for traditional Chinese medicine (TCM) analysis is presented, where the authors discuss the application of state-of-the-art CA for screening enzyme inhibitors and investigating the interactions between TCM and plasma proteins.
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