Journal ArticleDOI
Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats
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Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats and they were found to be more vulnerable to turmeric-induced hepatotoxicity than rats.About:
This article is published in Toxicology Letters.The article was published on 1998-05-01. It has received 67 citations till now.read more
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Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa)
TL;DR: Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti- inflammation activity and may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation.
Journal ArticleDOI
A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease
TL;DR: A study of curcumin in patients with AD is performed to gather information on the bioavailability, safety and tolerability of this promising agent in the treatment and/or prevention of AD.
Journal ArticleDOI
Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review
TL;DR: Turmeric and curcumin are nonmutagenic and are safe in pregnancy in animals but more studies in human are needed and there are still few trials and more studies are needed specially on nanoformulations.
Journal ArticleDOI
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.
Javad Sharifi-Rad,Youssef El Rayess,Alain Abi Rizk,Carmen Sadaka,Raviella Zgheib,Wissam Zam,Simona Sestito,Simona Rapposelli,Katarzyna Neffe-Skocińska,Dorota Zielińska,Bahare Salehi,William N. Setzer,Noura S. Dosoky,Yasaman Taheri,Marc El Beyrouthy,Miquel Martorell,Elise Adrian Ostrander,Hafiz Ansar Rasul Suleria,William C. Cho,Alfred Maroyi,Natália Martins +20 more
TL;DR: This review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, and cardioprotective effects.
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Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract
TL;DR: Curcuma phaeocaulis may be a useful drug among Curcuma species for acute inflammation, and the active constituents of C. phaeOCaulis are not curcuminoids, suggesting that curCuminoids' contents do not relate to inhibition of arthritis swelling.
References
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A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.
TL;DR: The methods used at present for the determination of the higher nucleic acids in organs are based on certain color reactions of their carbohydrate components, but if the quantitative estimations of desoxyribonucleic acid and of ribon nucleic acid could be based on phosphorus determinations rather than on color tests of their carbohydrates components, these difficulties might be avoided.
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Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.
Journal Article
Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound
TL;DR: Investigation of the chemopreventive action of dietary curcumin on azoxymethane-induced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phospholIPase C gamma 1, lipoxygenase, and cyclo oxygengenase activities in male F344 rats indicates that dietary administration ofCurcumin significantly inhibited incidence of colon adenocarcinomas.