Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.
Javad Sharifi-Rad,Youssef El Rayess,Alain Abi Rizk,Carmen Sadaka,Raviella Zgheib,Wissam Zam,Simona Sestito,Simona Rapposelli,Katarzyna Neffe-Skocińska,Dorota Zielińska,Bahare Salehi,William N. Setzer,Noura S. Dosoky,Yasaman Taheri,Marc El Beyrouthy,Miquel Martorell,Elise Adrian Ostrander,Hafiz Ansar Rasul Suleria,William C. Cho,Alfred Maroyi,Natália Martins +20 more
TLDR
This review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, and cardioprotective effects.Abstract:
Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, and cardioprotective effects. Bioavailability, bioefficacy and safety features, side effects, and quality parameters of curcumin are also addressed. Finally, curcumin's multidimensional applications, food attractiveness optimization, agro-industrial procedures to offset its instability and low bioavailability, health concerns, and upcoming strategies for clinical application are also covered.read more
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Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability.
Mohamed E. Abd El-Hack,Mohamed T. El-Saadony,Ayman A. Swelum,Muhammad Arif,Mahmoud M. Abo Ghanima,Mustafa Shukry,Ahmed E. Noreldin,Ayman E. Taha,Khaled A. El-Tarabily,Khaled A. El-Tarabily +9 more
TL;DR: A review of curcumin's biological properties is presented in this paper, where the most popular methods for encapsulation are discussed, including nanocomplexing, gelation, complex coacervation, electrospraying, and solvent-free pH-driven encapsulation.
Journal ArticleDOI
Neuroprotective Herbs for the Management of Alzheimer's Disease.
TL;DR: In this paper, a review of the role of neuroprotective herbs and their bioactive compounds for dementia associated with Alzheimer's disease and pre-Alzheimer's disease is presented.
Journal ArticleDOI
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline.
Giuseppe Caruso,Sebastiano Alfio Torrisi,Maria Paola Mogavero,Walter Currenti,Sabrina Castellano,Justyna Godos,Raffaele Ferri,Fabio Galvano,Gian Marco Leggio,Giuseppe Grosso,Filippo Caraci +10 more
TL;DR: In this paper, the authors discuss the potential mechanisms involved in age-related cognitive decline or early stage cognitive impairment and current evidence from clinical human studies conducted on polyphenols and the aforementioned outcomes.
Journal ArticleDOI
Functional importance of bioactive compounds of foods with Potential Health Benefits: A review on recent trends
Kolawole Banwo,Ayoyinka Olufunke Olojede,A.T. Adesulu-Dahunsi,Deepak Kumar Verma,Mamta Thakur,Soubhagya Tripathy,Smita Singh,Smita Singh,Ami Patel,Alok Kumar Gupta,Cristóbal N. Aguilar,Gemilang Lara Utama +11 more
TL;DR: The current study considers the health potential of BACs and their rising demand in form of functional foods in the world and their analytical methods, bioavailability and bioaccessibility.
References
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Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
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Mutational landscape and significance across 12 major cancer types
Cyriac Kandoth,Michael D. McLellan,Fabio Vandin,Kai Ye,Beifang Niu,Charles Lu,Mingchao Xie,Qunyuan Zhang,Joshua F. McMichael,Matthew A. Wyczalkowski,Mark D.M. Leiserson,Christopher A. Miller,John S. Welch,Matthew J. Walter,Michael C. Wendl,Timothy J. Ley,Richard K. Wilson,Benjamin J. Raphael,Li Ding +18 more
TL;DR: Data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types are presented as part of the TCGA Pan-Cancer effort, and clinical association analysis identifies genes having a significant effect on survival.
Journal Article
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Ann-Lii Cheng,Hsu Ch,Lin Jk,Hsu Mm,Yunn-Fang Ho,Shen Ts,Ko Jy,Lin Jt,Bor-Ru Lin,Ming-Shiang W,Yu Hs,Shiou-Hwa Jee,Chen Gs,Chen Tm,Chi-An Chen,Lai Mk,Yeong-Shiau Pu,Min-Hsiung Pan,Wang Yj,Tsai Cc,Hsieh Cy +20 more
TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
Journal ArticleDOI
Curcumin as “Curecumin”: From kitchen to clinic
TL;DR: Curcumin, a spice once relegated to the kitchen shelf, has moved into the clinic and may prove to be "Curecumin", a therapeutic agent in wound healing, diabetes, Alzheimer disease, Parkinson disease, cardiovascular disease, pulmonary disease, and arthritis.
Journal ArticleDOI
Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.