Sudden Cardiac Death in Systemic Sclerosis: Diagnostics to Assess Risk and Inform Management.
Laura Ross,E. Paratz,Murray Baron,Andre La Gerche,Mandana Nikpour +4 more
- Vol. 11, Iss: 10, pp 1781
TLDR
A review of the possible mechanisms of sudden cardiac death in systemic sclerosis and their current understanding of how each of these mechanisms may contribute to cardiac death can be found in this article, highlighting the need for a future research agenda that addresses the underlying epidemiology of SCD in SSc and identifies opportunities for intervention to modify the disease course of heart disease.Abstract:
Cardiac disease is a leading cause of death in systemic sclerosis (SSc) and sudden cardiac death (SCD) is thought to occur more commonly in SSc than in the general population. Diffuse myocardial fibrosis, myocarditis and ischaemic heart disease are all prevalent in SSc and can be reasonably hypothesised to contribute to an increased risk of SCD. Despite this, SCD remains a relatively understudied area of SSc with little understood about SSc-specific risk factors and opportunities for primary prevention. In this review, we present an overview of the possible mechanisms of SCD in SSc and our current understanding of how each of these mechanisms may contribute to cardiac death. This review highlights the need for a future research agenda that addresses the underlying epidemiology of SCD in SSc and identifies opportunities for intervention to modify the disease course of heart disease in SSc.read more
Citations
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Journal ArticleDOI
Systemic sclerosis
TL;DR: In this paper , the authors reviewed the multiple clinical dimensions of systemic sclerosis, beginning at a precursor very early stage of disease, with a focus on timely early detection of organ involvement.
Journal ArticleDOI
Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis
TL;DR: It is found that, in early phases of SSc, the expression of HO-1 in dermal fibroblast is lower compared to those isolated from healthy control individuals, and evidence of the role ofHO-1/carbon monoxide (CO) signaling pathway in calcium handling is shown.
Journal ArticleDOI
Heart disease in the course of systemic sclerosis – an observational study
Anna Nowakowska-Płaza,Jakub Wroński,Joanna Werońska-Tatara,Agnieszka Foryś,Alicja Kraska,Malgorzata Wislowska +5 more
TL;DR: In this paper , the clinical characteristics of patients with and without heart involvement in the course of systemic sclerosis (SSc) were compared and the major type of cardiac involvement was myocarditis (71%).
Journal ArticleDOI
Cardiac involved and autopsy in two patients with systemic sclerosis: Two cases report
TL;DR: In this article , the authors found that chronic inflammation of the heart may lead to extensive fibrosis, which could contribute to the high mortality rate observed in systemic sclerosis patients. But the pathogenesis of cardiac death is not very clear.
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