Journal ArticleDOI
Synergistic interactions between cannabinoid and opioid analgesics
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TLDR
The aim of such studies is to develop a novel analgesic regimen using low dose combinations of cannabinoids and opioids to effectively treat acute and chronic pain, especially pain that may be resistant to opioids alone.About:
This article is published in Life Sciences.The article was published on 2004-01-30. It has received 274 citations till now. The article focuses on the topics: Opioid & Chronic pain.read more
Citations
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The endocannabinoid system and its therapeutic exploitation
TL;DR: The conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come are explored.
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Molecular mechanisms of opioid receptor-dependent signaling and behavior.
TL;DR: There is a continued need for more translational work on opioid receptors in vivo and the authors put into context how opioid receptor signaling leads to the modulation of behavior with the potential for therapeutic intervention.
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Paracetamol: New Vistas of an Old Drug
Alfio Bertolini,Anna Ferrari,Alessandra Ottani,Simona Guerzoni,Raffaella Tacchi,Sheila Leone +5 more
TL;DR: These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones.
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Emerging strategies for exploiting cannabinoid receptor agonists as medicines
TL;DR: Five strategies that have the potential to meet either the efficacy and/or the benefit‐to‐risk ratio of a cannabinoid receptor agonist are focused on.
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Practical considerations in medical cannabis administration and dosing
TL;DR: Suggestions are offered on cannabis-drug interactions, patient monitoring, and standards of care, while special cases for cannabis therapeutics are addressed: epilepsy, cancer palliation and primary treatment, chronic pain, use in the elderly, Parkinson disease, paediatrics, with concomitant opioids, and in relation to driving and hazardous activities.
References
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Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
TL;DR: The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement.
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Anatomy of CNS opioid receptors
TL;DR: There is a wide body of evidence to suggest the existence of at least three distinct opioid receptor types in the CNS, referred to as μ, δ, and κ, and their relation to the opioid peptides is discussed.
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Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain
TL;DR: The authors describe a relationship between the distribution of opiate receptors and of neurotransmitters that varies dramatically throughout the human and monkey brain.
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Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry.
TL;DR: This study provides, for the first time, indirect assessment of the neurons containing cannabinoid receptor in the entire adult rat brain and will serve as a basis for future direct morphological confirmation using receptor immunohistochemistry and for functional studies.
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Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.
TL;DR: Two studies show that heterodimers exhibit distinct ligand binding and signaling characteristics, which may provide new foundations for more effective therapies.