Journal ArticleDOI
Synthesis and Bioactivity of Guanidinium-Functionalized Pillar[5]arene as a Biofilm Disruptor
Shuwen Guo,Qiaoxian Huang,Yuan Chen,Jianwen Wei,Jun Zheng,Leyong Wang,Yitao Wang,Ruibing Wang +7 more
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TLDR
A novel guanidinium-functionalized pillar[5]arene (GP5) that exhibited a high antibacterial potency against Gram-negative E. coli and Gram-positive S. aureus strains was designed and synthesized, providing a novel supramolecular platform to effectively disrupt biofilms.Abstract:
Due to the inherent resistance of bacterial biofilms to antibiotics and their serious threat to global public health, novel therapeutic agents and strategies to tackle biofilms are urgently needed. To this end, we designed and synthesized a novel guanidinium-functionalized pillar[5]arene (GP5) that exhibited high antibacterial potency against Gram-negative E. coli (BH101) and Gram-positive S. aureus (ATCC25904) strains. More importantly, GP5 effectively disrupted preformed E. coli biofilms by efficient penetration through biofilm barriers and subsequent destruction of biofilm-enclosed bacteria. Furthermore, host-guest complexation between GP5 and cefazolin sodium, a conventional antibiotic that otherwise shows negligible activity against biofilms, exhibited much enhanced, synergistic disruption activity against E. coli biofilms, thus providing a novel supramolecular platform to effectively disrupt biofilms.read more
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Multicharged cyclodextrin supramolecular assemblies.
Zhixue Liu,Yu Liu +1 more
TL;DR: This review focuses on summarizing the recent advances in positively/negatively charged CDs and parent CDs encapsulating positively/Negatively charged guests, especially the construction process of supramolecular assemblies and their applications.
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Functional Materials with Pillarene Struts
TL;DR: ConspectusPillar[n]arenes (pillarenes for short) are a relatively new generation of macrocyclic host compounds with rigid cylinder architectures containing several hydroquinone units that are bridg...
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Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors.
TL;DR: In this paper, a class of quinazolone thiazoles was identified as new structural scaffolds for potential antibacterial conquerors to tackle dreadful resistance, and the most representative 5j featuring the 4-trifluoromethylphenyl group possessed superior performances against Escherichia coli and Pseudomonas aeruginosa to norfloxacin.
Journal ArticleDOI
Combating antibiotic resistance: Current strategies for the discovery of novel antibacterial materials based on macrocycle supramolecular chemistry
TL;DR: This review will briefly present basic concepts, novel strategies, and unique antibacterial activities of different antibacterial materials based on different supramolecular macrocycles, which may open an alternative way to complement traditional drugs, facilitate the development of modern medicine, and overcome the antibiotic-resistance crisis.
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Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies
TL;DR: In this article , the structure and properties of advanced antimicrobial cationic polymers with low toxicity and high selectivity are surveyed. And their uses as potentiating adjuvants and as antibiofilm agents are also covered.
References
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Journal ArticleDOI
Pillar-Shaped Macrocyclic Hosts Pillar[n]arenes: New Key Players for Supramolecular Chemistry
TL;DR: This Review has provided historical background to macrocyclic chemistry, followed by a detailed discussion of the fundamental properties of pillar[n]arenes, including their synthesis, structure, and host-guest properties.
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Supramolecular Amphiphiles Based on Host-Guest Molecular Recognition Motifs.
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Biodegradable nanostructures with selective lysis of microbial membranes
Fredrik Nederberg,Ying Zhang,Jeremy P. K. Tan,Kaijin Xu,Huaying Wang,Chuan Yang,Shujun Gao,Xin Dong Guo,Kazuki Fukushima,Lanjuan Li,James L. Hedrick,Yi Yan Yang +11 more
TL;DR: It is demonstrated that the nanoparticles disrupt microbial walls/membranes selectively and efficiently, thus inhibiting the growth of Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and fungi, without inducing significant haemolysis over a wide range of concentrations.
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Use of the fluorescent probe 1-N-phenylnaphthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa.
TL;DR: Results are consistent with the concept that aminoglycosides interact as a divalent cation binding site on the P. aeruginosa outer membrane and permeabilize it to the hydrophobic fluorescent probe 1-N-phenylnaphthylamine (NPN).
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Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
Kieron M. G. O'Connell,James T. Hodgkinson,Hannah F. Sore,Martin Welch,George P. C. Salmond,David R. Spring +5 more
TL;DR: The introduction of effective antibacterial therapies for infectious diseases in the mid-20th century completely revolutionized clinical practices and helped to facilitate the development of modern medicine.