Journal ArticleDOI
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.
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TLDR
A series of 2-(2,6-dihalophenyl)-3-(substituted pyrimidinyl)-1,3-thiazolidin-4-ones designed on the prediction of quantitative structure-activity relationship studies, synthesized, and evaluated as HIV-1 reverse transcriptase inhibitors showed that compounds 4m and 4n were highly active in inhibiting HIV- 1 replication.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2007-05-01. It has received 120 citations till now. The article focuses on the topics: Quantitative structure–activity relationship.read more
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Recent developments and biological activities of thiazolidinone derivatives: A review
TL;DR: This review aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011 and presents data for active compounds, some of which have passed the preclinical testing stage.
Journal ArticleDOI
4-Thiazolidinones: the advances continue….
Avinash C. Tripathi,Shiv Gupta,Gul Naz Fatima,Pankaj Kumar Sonar,Amit Verma,Shailendra K. Saraf +5 more
TL;DR: The last section of the review encompasses the various patents granted on 4-thiazolidinone analogs/derivatives with World Intellectual Proprietary Organization and United State Patent Trademark Office (USPTO), particularly in the duration of the year 2000 to the year 2012.
Journal ArticleDOI
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: synthesis, anti-inflammatory and antimicrobial evaluation.
Ashish P. Keche,Girish D. Hatnapure,Rajesh H. Tale,Atish H. Rodge,Satish S. Birajdar,Vandana M. Kamble +5 more
TL;DR: Biological data revealed that among all the compounds screened, compounds 5, 6, 11, 12, 16 and 20 were found to have moderate to potent anti-inflammatory activity and promising antimicrobial activity against all the selected pathogenic bacteria and fungi.
Journal ArticleDOI
Nano-Fe3O4@SiO2 supported ionic liquid as an efficient catalyst for the synthesis of 1,3-thiazolidin-4-ones under solvent-free conditions
Naghmeh Azgomi,Masoud Mokhtary +1 more
TL;DR: In this article, a magnetically supported ionic liquid on Fe 3 O 4 @SiO 2 nanoparticles (MNPs@ SiO 2 -IL) was synthesized and evaluated as a recoverable catalyst for the one-pot synthesis of 1,3-thiazolidin-4-ones in high to excellent yield under solvent-free conditions.
Journal ArticleDOI
Synthetic and medicinal perspective of thiazolidinones: A review
Sundeep Kaur Manjal,Ramandeep Kaur,Rohit Bhatia,Kapil Kumar,Virender Singh,Ravi Shankar,Rupinder Kaur,Ravindra K. Rawal +7 more
TL;DR: An attempt has been made by the authors to summarize various synthetic strategies for thiazolidinone derivatives as well as their biological significance.
References
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Journal ArticleDOI
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
Rudi Pauwels,Jan Balzarini,Masanori Baba,Robert Snoeck,Dominique Schols,Piet Herdewijn,Jan Desmyter,Erik De Clercq +7 more
TL;DR: A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation of anti-HIV agents, which significantly reduced labor time as compared to the trypan blue exclusion method, and permits the evaluation of large numbers of compounds for their anti-hIV activity.
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Structural biology of HIV
TL;DR: The human immunodeficiency virus (HIV) genome encodes a total of three structural proteins, two envelope proteins, three enzymes, and six accessory proteins as mentioned in this paper, which have been provided high-resolution three-dimensional structural information over the past ten years.
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Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents
Maria Letizia Barreca,Alba Chimirri,Laura De Luca,Anna-Maria Monforte,Pietro Monforte,A. Rao,Maria Zappalà,Jan Balzarini,Erik De Clercq,Christophe Pannecouque,Myriam Witvrouw +10 more
TL;DR: SAR studies evidenced that the nature of the substituents at the 2 and 3 positions of the thiazolidinone nucleus largely influenced the in vitro anti-HIV activity of this new class of potent antiviral agents.
Journal ArticleDOI
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT inhibitors.
TL;DR: An attempt in correlating the derived physicochemical properties with the HIV-RT inhibitory activity resulted in some statistically significant QSAR models with good predictive ability.