Journal ArticleDOI
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
TLDR
No clear correlation was observed between the antiepileptic activity and molecular lipophilicity descriptors of the tested compounds, and some selected compounds were assayed against seizures induced by pentylenetetrazole and strychnine in mice.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2008-05-15. It has received 134 citations till now. The article focuses on the topics: Anticonvulsant Agent & Anticonvulsant.read more
Citations
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Journal ArticleDOI
Current Developments of Coumarin Compounds in Medicinal Chemistry
TL;DR: The whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains are presented.
Journal ArticleDOI
Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery.
TL;DR: The most important biological effects of thiazole-based compounds are reviewed and their roles in new leads identification and drug discovery are highlighted to help researches for finding potential future directions on the development of more potent and specific analogs of th Diazole- based compounds for various biological targets.
Journal ArticleDOI
4-Thiazolidinones: the advances continue….
Avinash C. Tripathi,Shiv Gupta,Gul Naz Fatima,Pankaj Kumar Sonar,Amit Verma,Shailendra K. Saraf +5 more
TL;DR: The last section of the review encompasses the various patents granted on 4-thiazolidinone analogs/derivatives with World Intellectual Proprietary Organization and United State Patent Trademark Office (USPTO), particularly in the duration of the year 2000 to the year 2012.
Journal ArticleDOI
Thiazoles: having diverse biological activities
Shiv Jee Kashyap,Vipin Kumar Garg,Pankaj Sharma,Nitin Kumar,Rupesh Dudhe,Jitendra Kumar Gupta +5 more
TL;DR: This review presents the up to date development on the design and development of different thiazole derivatives.
Journal ArticleDOI
Recent developments of coumarin-containing derivatives and their anti-tubercular activity
TL;DR: This review outlines the advances in the application of coumarin-containing derivatives as anti-TB agents and the critical aspects of design and structure-activity relationship of these derivatives.
References
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Book
Foye's Principles of Medicinal Chemistry
TL;DR: This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy.
Journal ArticleDOI
Statistical Method in Biological Assay
TL;DR: Statistical Method in Biological AssayBy Dr. D. J. Finney.
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Mechanisms of Action of Antiepileptic Drugs
TL;DR: Gabapentin, designed as a precursor of GABA easily entering the brain, was shown to increase brain synaptic GABA, and novel antiepileptic drugs acting selectively through the GABA-ergic system are tiagabine and vigabatrin.
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