Journal ArticleDOI
Synthesis, characterization and cytotoxic studies of diamine and diimine palladium(II) complexes of diethyldithiocarbamate and binding of these and analogous platinum(II) complexes with DNA
TLDR
Three palladium (II) complexes of 2, 2′-bipyridine (bipy), 1, 10-phenanthroline (phen) and 1, 2-diaminocyclohexane (dach) with diethyldithiocarbamate (ddtc) have been synthesized and characterized.About:
This article is published in Inorganica Chimica Acta.The article was published on 1989-12-01. It has received 85 citations till now. The article focuses on the topics: Fluorescence spectrometry & Cooperative binding.read more
Citations
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Palladium coordination compounds as anti-viral, anti-fungal, anti-microbial and anti-tumor agents
TL;DR: In this article, the anti-tumor, anti-fungal and anti-microbial properties of new Pd(II) complexes are compared with similar properties of other metals.
Journal ArticleDOI
Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes.
TL;DR: This review provides readers with an up to date account of the advances that have taken place over the past several decades in platinum-based chemotherapeutic agents, i.e. through interactions with DNA.
Journal ArticleDOI
Synthesis, characterization and biological activity of lanthanum(III) complexes containing 2-methylene-1,10-phenanthroline units bridged by aliphatic diamines.
Fenghua Li,Guanghua Zhao,Guanghua Zhao,Hongxing Wu,Hai Lin,Xiang-Xia Wu,Shou-Rong Zhu,Huakuan Lin +7 more
TL;DR: DNA-binding studies indicate that, besides the intercalation, the complexes bind to DNA by the other interaction(s), which might be responsible for the production of more compact DNA, coinciding with more A-like feature of DNA as suggested by CD spectra.
Journal ArticleDOI
Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: synthesis, characterization and cell assay
Giuseppina Faraglia,Dolores Fregona,Sergio Sitran,Lorena Giovagnini,Cristina Marzano,Francarosa Baccichetti,Umberto Casellato,Rodolfo Graziani +7 more
TL;DR: The [M(ESDT)Cl]n species have been reacted with various amines in dichloromethane or chloroform to obtain mixed ligand complexes and the dithiocarbamato intermediates have been tested for in vitro cytostatic activity against human leukemic HL-60 and HeLa cells.
Journal ArticleDOI
2,2′-Bipyridinebutyldithiocarbamatoplatinum(II) and palladium(II) complexes: Synthesis, characterization, cytotoxicity, and rich DNA-binding studies
TL;DR: In the interaction studies between the Pt( II) and Pd(II) complexes with DNA, several binding and thermodynamic parameters have been determined, which may provide deeper insights into the mechanism of action of these types of complexes with nucleic acids.
References
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Journal ArticleDOI
The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.
TL;DR: The results indicate that the binding of any non-interacting ligand covering more than one lattice residue results in non- linear (convex downward) Scatchard plots, and the introduction of positive ligand-ligand co-operativity antagonizes this non-linearity, and eventually leads to plots of the opposite curvature.
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Studies of the binding of actinomycin and related compounds to DNA
Werner Müller,Donald M. Crothers +1 more
TL;DR: The physical property which distinguishes actinomycin from the simpler analogs (which lack biological activity) is a very slow dissociation reaction, several orders of magnitude slower than for the non-active analogs.
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Binding of platinum and palladium metallointercalation reagents and antitumor drugs to closed and open DNAs.
TL;DR: Long-term interactions of metal complexes with PM-2 DNAs I, I0, and II, corresponding tosuperhelical, closed relaxed, and nicked circles, showed that covalent binding occurs the most readily to DNA I, possibly because of the presence of underwound duplex regions in this tightly wound superhelical DNA.
Journal Article
Effect of Diethyldithiocarbamate on cis-Diamminedichloroplatinum(II)-induced Cytotoxicity, DNA Cross-Linking, and γ-Glutamyl Transpeptidase Inhibition
TL;DR: Data indicate that DDTC has unique chemical specificity in its reactions with platinum complexes and that this specificity is ideal for application as a chemoprotective drug against cis-platinum toxicity.