Journal ArticleDOI
Synthesis of 1,8-Dioxo-decahydroacridine Derivatives via Ru-Catalyzed Acceptorless Dehydrogenative Multicomponent Reaction.
Nandita Biswas,Dipankar Srimani +1 more
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TLDR
In this article, a Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed to synthesize biologically active 1,8-dioxodecahydroacridine derivatives.Abstract:
A Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed. This reaction offers a cost-effective and simple operational strategy to synthesize biologically active 1,8-dioxodecahydroacridine derivatives. The protocol provides a wide range of substrate scope and various functional groups are also well tolerated under the reaction condition. To shed light on the mechanistic and kinetic study, some controlled experiments and deuterium labeling experiments were executed. A time-dependent product distribution experiment is also presented and the reaction scale-up is performed to highlight the practical utility of this strategy.read more
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New Ruthenium (II) Catalysts Enable the Synthesis of 2-Amino-4H-chromenes Using Primary Alcohols via Acceptorless Dehydrogenative Coupling
TL;DR: A series of biologically important 2-amino-4H-chromenes functionalized with different substituents has been synthesized through one-pot multicomponent reaction catalysed by p-cymene Ru(II) organometallic complexes encompassing N˄O chelated carbazole based hydrazone ligands as discussed by the authors .
Posted ContentDOI
One Pot Three Component Synthesis of Substituted 3,4,6,7-Tetrahydro-3,3,6,6-Tetramethyl-9,10-Diphenylacridine-1,8(2H,5H,9H,10H)-Diones Catalyzed by Mesostrucrted In2O3-SiO2
TL;DR: In this paper, a convenient one-pot synthesis of heterocyclic nucleous acridine derivative compound has been achieved, where the mixture of dimedone, substituted benzaldehyde and aniline were catalyzed by efficient In2O3-SiO2 heterogeneous reusable catalyst in ethanol to obtain the desired acridines derivatives with good yield.
Journal ArticleDOI
An overview of Ruthenium-catalyzed multicomponent reactions
TL;DR: Ruthenium-catalyzed multicomponent reactions (MCRs) as discussed by the authors is an unrivalled synthetic technique and is used by chemists at an accelerating rate in recent years.
Journal ArticleDOI
Acid Catalyzed Multicomponent One-Pot Synthesis of New Quinazolinone based Unsymmetrical C-N Linked Bis Heterocycles
TL;DR: In this article , a series of unsymmetrical C-N linked bis heterocycles bearing quinazolinone and acridinedione skeletons have been synthesized in an acid promoted one pot multicomponent reaction.
Journal ArticleDOI
Fe-mediated oxidative cascade [1 + 2 + 3]-cyclization/esterification reaction: synthesis of 4-alkylated 1,4-dihydropyridines.
TL;DR: In this article , an Fe-mediated four-component reaction of enaminones, anhydrides and tetrahydrofuran through a cascade [1 + 2 + 3]-cyclization/esterification process is presented.
References
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Journal ArticleDOI
Nanocrystalline TiO2, via green combustion synthesis, as an efficient and reusable catalyst for the preparation of 1,8‐dioxooctahydroxanthenes and 1,8‐dioxodecahydroacridines
TL;DR: In this paper, Nanocrystalline TiO2 is synthesized using a green combustion method and used as a recyclable catalyst for the one-pot multicomponent synthesis of 1,8-dioxodecahydroacridines and 1, 8 -dioxooctahydroxanthenes, under solvent-free conditions.
Journal ArticleDOI
Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions
TL;DR: In this article, a cascade cyclization of enaminones and aldehydes in different media (EtOH/CH3CN) was proposed to synthesize dual 1,4-dihydropyridines with several substituted patterns.
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Cross-dehydrogenative regioselective Csp3–Csp2 coupling of enamino-ketones followed by rearrangement: an amazing formation route to acridine-1,8-dione derivatives
TL;DR: A new general method for the synthesis of acridine-1,8-diones through CDC coupling of enamino-ketones followed by rearrangement in the presence of PTSA under an aerobic atmosphere has been developed.
Journal ArticleDOI
Immobilization of organofunctionalized silica (SiMPTMS) with biphenyl-2,2′-dioic acid and investigation of its catalytic property for one-pot tandem synthesis of acridine-1,8-dione derivatives
TL;DR: In this paper, the MPTMS-modified silica immobilized with biphenyl-2,2′-dioic acid has been used for the synthesis of acridine-1,8-dione derivatives.