Journal ArticleDOI
Synthesis of 1,8-Dioxo-decahydroacridine Derivatives via Ru-Catalyzed Acceptorless Dehydrogenative Multicomponent Reaction.
Nandita Biswas,Dipankar Srimani +1 more
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TLDR
In this article, a Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed to synthesize biologically active 1,8-dioxodecahydroacridine derivatives.Abstract:
A Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed. This reaction offers a cost-effective and simple operational strategy to synthesize biologically active 1,8-dioxodecahydroacridine derivatives. The protocol provides a wide range of substrate scope and various functional groups are also well tolerated under the reaction condition. To shed light on the mechanistic and kinetic study, some controlled experiments and deuterium labeling experiments were executed. A time-dependent product distribution experiment is also presented and the reaction scale-up is performed to highlight the practical utility of this strategy.read more
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New Ruthenium (II) Catalysts Enable the Synthesis of 2-Amino-4H-chromenes Using Primary Alcohols via Acceptorless Dehydrogenative Coupling
TL;DR: A series of biologically important 2-amino-4H-chromenes functionalized with different substituents has been synthesized through one-pot multicomponent reaction catalysed by p-cymene Ru(II) organometallic complexes encompassing N˄O chelated carbazole based hydrazone ligands as discussed by the authors .
Posted ContentDOI
One Pot Three Component Synthesis of Substituted 3,4,6,7-Tetrahydro-3,3,6,6-Tetramethyl-9,10-Diphenylacridine-1,8(2H,5H,9H,10H)-Diones Catalyzed by Mesostrucrted In2O3-SiO2
TL;DR: In this paper, a convenient one-pot synthesis of heterocyclic nucleous acridine derivative compound has been achieved, where the mixture of dimedone, substituted benzaldehyde and aniline were catalyzed by efficient In2O3-SiO2 heterogeneous reusable catalyst in ethanol to obtain the desired acridines derivatives with good yield.
Journal ArticleDOI
An overview of Ruthenium-catalyzed multicomponent reactions
TL;DR: Ruthenium-catalyzed multicomponent reactions (MCRs) as discussed by the authors is an unrivalled synthetic technique and is used by chemists at an accelerating rate in recent years.
Journal ArticleDOI
Acid Catalyzed Multicomponent One-Pot Synthesis of New Quinazolinone based Unsymmetrical C-N Linked Bis Heterocycles
TL;DR: In this article , a series of unsymmetrical C-N linked bis heterocycles bearing quinazolinone and acridinedione skeletons have been synthesized in an acid promoted one pot multicomponent reaction.
Journal ArticleDOI
Fe-mediated oxidative cascade [1 + 2 + 3]-cyclization/esterification reaction: synthesis of 4-alkylated 1,4-dihydropyridines.
TL;DR: In this article , an Fe-mediated four-component reaction of enaminones, anhydrides and tetrahydrofuran through a cascade [1 + 2 + 3]-cyclization/esterification process is presented.
References
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Sustainable Synthesis of Quinazoline and 2-Aminoquinoline via Dehydrogenative Coupling of 2-Aminobenzyl Alcohol and Nitrile Catalyzed by Phosphine-Free Manganese Pincer Complex.
TL;DR: A one-pot synthetic strategy for the synthesis of 2-alkylaminoquinolines through sequential dehydrogenative annulation and N-alkylation reaction has also been demonstrated.
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Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies
TL;DR: A systematic review will provide the synthetic organic community with a conceptual overview and comprehensive understanding of the different multicomponent reaction (MCR) cascades involving dearomatization as the characteristic step and help researchers to look at this promising area from a different perspective with respect to drug discovery, new MCR-based disconnections and often hidden opportunities.
Journal ArticleDOI
Recent Advancement on Sustainable Synthesis of N-heterocycles Following Acceptorless Dehydrogenative Coupling Protocol Using Alcohols
TL;DR: In this article, a review of homogeneous and heterogeneously catalyzed recent advancements in the synthesis of heterocycles following the transition metal-catalyzed acceptorless dehydrogenative coupling (ADC) approach is presented.
Journal ArticleDOI
Review on the Ugi Multicomponent Reaction Mechanism and the Use of Fluorescent Derivatives as Functional Chromophores
TL;DR: The present mini-review discusses the findings, controversies, and gaps observed for the Ugi four-component reaction, and the new trend of functional chromophore synthesis by MCRs is highlighted.
Journal ArticleDOI
Acceptorless Dehydrogenative Coupling Using Ammonia: Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium
TL;DR: The synthesis of N-heteroaromatic compounds via an acceptorless dehydrogenative coupling process involving direct use of ammonia as the nitrogen source was explored and the synthesis of pyrazine derivatives from 1,2-diols was reported.