Journal ArticleDOI
Synthesis of 3-substituted indoles promoted by pulverization-activation method catalyzed by Bi(NO3)3·5H2O
Mohammad Mehdi Khodaei,Parvin Ghanbary,Iraj Mohammadpoor-Baltork,Hamid Reza Memarian,Ahmad Reza Khosropour,Kobra Nikoofar +5 more
TLDR
In this paper, a new, facile, efficient, "green" and chemoselective procedure for the synthesis of indole derivatives has been developed with pulverization-activation method catalyzed by Bi(NO3)3·5H2O (PAMC-Bi(NO 3)3 ·5H 2O) through grinding of indoles with aldehydes or Michael acceptors.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-03-01. It has received 37 citations till now. The article focuses on the topics: Indole test & Catalysis.read more
Citations
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Aluminum chloride–catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives
TL;DR: In this paper, the AlCl3-catalyzed alkylation of pyrrole (2) with chalcone (1a-i) at a ratio of 8:1 in the presence of 10−mol% AlCl 3 gave the solely 2-alkyl pyrroles (3a−i) and indole (7) at room temperature for 12 in good yields.
Journal ArticleDOI
The Michael addition of indoles and pyrrole to α -, β -unsaturated ketones and double-conjugate 1,4-addition of indoles to symmetric enones promoted by pulverization-activation method and Thia-Michael addition catalyzed by wet cyanuric chloride
TL;DR: A new, facile, and efficient procedure for conjugate addition of indole and pyrrole with Michael acceptors have been developed for pulverization–activation reaction catalyzed by wet cyanuric chloride through grinding under solvent-free conditions at room temperature.
Journal ArticleDOI
Bis-indolylation of aldehydes and ketones using silica-supported FeCl3: molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites
TL;DR: The study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 Mpro enzyme by interacting with key amino acid residues of the active sites via hydrophobic as well as hydrogen bonding interactions.
Journal ArticleDOI
V 2 O 5 /SiO 2 as a Heterogeneous Catalyst in the Synthesis of bis(indolyl)methanes Under Solvent Free Condition
TL;DR: In this article, the authors proposed an efficient and facile approach for the synthesis of bis(indolyl)methanes through a catalytic one pot reaction, in which Indole and aromatic aldehydes were stirred in the presence of a prepared and characterized heterogeneous catalyst V2 O676 5/SiO2 at 50∘C under solvent free condition.
Journal ArticleDOI
A domino electro-oxidative synthesis of 3,3′-bis(indolyl)methane nanoparticles
Kobra Nikoofar,Khadijeh Ghanbari +1 more
TL;DR: In this article, an effective route for electro-oxidative synthesis of 3,3′-bis(indolyl)methane nanoparticles has been described via a domino multi-component reaction between various alcohols and indole derivatives in an undivided cell under constant potential conditions in CH3CN at room temperature.
References
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Journal ArticleDOI
Bismuth Nitrate-Catalyzed Versatile Michael Reactions†
Neeta Srivastava,Bimal K. Banik +1 more
TL;DR: Bismuth nitrate-catalyzed versatile Michael reaction was developed to reduce the complications that characterize the current standard Michael reaction and used for facile preparation of organic compounds of widely different structures.
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Molecular iodine-catalyzed efficient and highly rapid synthesis of bis(indolyl)methanes under mild conditions
TL;DR: Highly rapid and efficient electrophilic substitution reactions of indoles with various aldehydes and ketones were carried out using I2 in CH3CN to afford the corresponding bis(indolyl)methanes in excellent yields.
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Sequential One-Pot InBr3-Catalyzed 1,4- then 1,2-Nucleophilic Addition to Enones
Marco Bandini,Pier Giorgio Cozzi,Massimo Giacomini,Paolo Melchiorre,Simona Selva,Achille Umani‐Ronchi +5 more
TL;DR: With the optimized atom-efficient protocol, several polyfunctionalized alpha-silyloxy cyanohydrins were synthesized in good to excellent yields and a notable level of simple 1,3-diastereoselection was recorded in the case of 2-cyclohexen-1-one 2c.
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Indolyl carboxylic acids by condensation of indoles with alpha-keto acids.
TL;DR: The indole derivatives 2,2-bis(3,3'-indolyl)propionic acid (1); 1,1,1,-tris(3-3-,3"-indolyls)ethane (2); and 2-2-isocaproic acid (3) were isolated from solvent extracts of indole-supplemented supernatants of Escherichia coli and corynebacteria.
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Lewis acid-catalyzed reactions in protic media. Lanthanide-catalyzed reactions of indoles with aldehydes or ketones
TL;DR: In this paper, Lanthanide triflates were found to be effective catalysts for reactions of indoles with aldehydes or ketones in aqueous solution.