Open AccessJournal Article
Synthesis of (â)-Oxycodone
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TLDR
This novel synthetic route to (-)-oxycodone, a semisynthetic opioid analgesic, features a palladium-catalyzed direct intramolecular arylation of an aryl bromide, oxidative dearomatization of a dihydrophenanthrenol, formation of a benzylic quaternary carbon by an intramolescular Michael addition of a malonate moiety.About:
This article is published in Organic Letters.The article was published on 2014-01-01 and is currently open access. It has received 27 citations till now.read more
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Reductive Amination in the Synthesis of Pharmaceuticals.
Oleg I. Afanasyev,Ekaterina A. Kuchuk,Dmitry L. Usanov,Denis Chusov,Denis Chusov,Denis Chusov +5 more
TL;DR: This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination according to the principle of action and a general synthetic scheme is provided for each compound.
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Prescribed drugs containing nitrogen heterocycles: an overview
TL;DR: A comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways is presented in this paper, where the reported examples are actually limited to current top selling drugs and their synthetic information has been extracted from both scientific journals and the wider patent literature.
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Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis
TL;DR: This review will focus on recent employment of 1,2-Carbon atom rearrangement in the total synthesis of natural products, highlighting the exceptional utility of such synthetic methodologies in the construction of intricate carbocycles, heterocycles or structurally complex motifs from synthetically more accessible precursors.
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Oxycodone self-administration in male and female rats
TL;DR: In this article, male and female Sprague-Dawley rats were implanted with jugular vein catheters and trained to self-administer oxycodone (0.03 milligram/kg/infusion) under fixed ratio 1 (FR1), FR2, and FR5 schedules of reinforcement followed by a dose-response study to assess sensitivity to the reinforcing effects of the drug.
Journal ArticleDOI
Minimalist Relativistic Force Field: Prediction of Proton–Proton Coupling Constants in 1H NMR Spectra Is Perfected with NBO Hybridization Parameters
TL;DR: In this paper, the authors used NBO hybridization coefficients for carbon atoms in the involved C-H bonds to simplify the parametric scaling of Fermi contacts to achieve fast and accurate prediction of proton-proton spin-spin coupling constants (SSCC) in 1H NMR.
References
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Journal ArticleDOI
Oxycodone self-administration in male and female rats
TL;DR: In this article, male and female Sprague-Dawley rats were implanted with jugular vein catheters and trained to self-administer oxycodone (0.03 milligram/kg/infusion) under fixed ratio 1 (FR1), FR2, and FR5 schedules of reinforcement followed by a dose-response study to assess sensitivity to the reinforcing effects of the drug.
Journal ArticleDOI
Minimalist Relativistic Force Field: Prediction of Proton–Proton Coupling Constants in 1H NMR Spectra Is Perfected with NBO Hybridization Parameters
TL;DR: In this paper, the authors used NBO hybridization coefficients for carbon atoms in the involved C-H bonds to simplify the parametric scaling of Fermi contacts to achieve fast and accurate prediction of proton-proton spin-spin coupling constants (SSCC) in 1H NMR.
Journal ArticleDOI
Studies culminating in the total synthesis of (dl)-morphine
Journal ArticleDOI
Total Synthesis of (S)-Equol
Jennifer M. Heemstra,Sean Kerrigan,Daniel R. Doerge,William G. Helferich,Willia m A. Boulanger +4 more
TL;DR: The first enantioselective total synthesis of (S)-equol is reported, which relies on an Evans alkylation to form the stereocenter and an intramolecular Buchwald etherification to generate the chroman ring.
Journal ArticleDOI
Indanol-Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization
TL;DR: The catalyst architecture exhibits the advantage of high modularity and thereby expedites catalyst optimization and was optimized for the challenging and highly sought-after hydrative dearomatization of 2-substituted phenols at the 4-position.