Journal ArticleDOI
Synthesis of Manganese Ferrite/Graphene Oxide Nanocomposites for Biomedical Applications
Erwin Peng,Eugene Shi Guang Choo,Prashant Chandrasekharan,Chang-Tong Yang,Jun Ding,Kai-Hsiang Chuang,Junmin Xue +6 more
TLDR
It is demonstrated that the loading of magnetic nanocrystals can be tuned by varying the ratio of graphene oxide/magnetic nanoparticles, and MGONCs are promising as magnetic resonance imaging (MRI) T(2) contrast agents.Abstract:
In this study, MnFe(2)O(4) nanoparticle (MFNP)-decorated graphene oxide nanocomposites (MGONCs) are prepared through a simple mini-emulsion and solvent evaporation process. It is demonstrated that the loading of magnetic nanocrystals can be tuned by varying the ratio of graphene oxide/magnetic nanoparticles. On top of that, the hydrodynamic size range of the obtained nanocomposites can be optimized by varying the sonication time during the emulsion process. By fine-tuning the sonication time, MGONCs as small as 56.8 ± 1.1 nm, 55.0 ± 0.6 nm and 56.2 ± 0.4 nm loaded with 6 nm, 11 nm, and 14 nm MFNPs, respectively, are successfully fabricated. In order to improve the colloidal stability of MGONCs in physiological solutions (e.g., phosphate buffered saline or PBS solution), MGONCs are further conjugated with polyethylene glycol (PEG). Heating by exposing MGONCs samples to an alternating magnetic field (AMF) show that the obtained nanocomposites are efficient hyperthermia agents. At concentrations as low as 0.1 mg Fe mL(-1) and under an 59.99 kA m(-1) field, the highest specific absorption rate (SAR) recorded is 1588.83 W g(-1) for MGONCs loaded with 14 nm MFNPs. It is also demonstrated that MGONCs are promising as magnetic resonance imaging (MRI) T(2) contrast agents. A T(2) relaxivity value (r(2) ) as high as 256.2 (mM Fe)(-1) s(-1) could be achieved with MGONCs loaded with 14 nm MFNPs. The cytotoxicity results show that PEGylated MGONCs exhibit an excellent biocompatibility that is suitable for biomedical applications.read more
Citations
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Journal ArticleDOI
Enhanced microwave absorption property of reduced graphene oxide (RGO)-MnFe2O4 nanocomposites and polyvinylidene fluoride.
Xiao-Juan Zhang,Guang-Sheng Wang,Wen-Qiang Cao,Yun-Zhao Wei,Junfei Liang,Lin Guo,Mao-Sheng Cao +6 more
TL;DR: The results indicated that the RGO/MnFe2O4/PVDF composites show the most excellent wave absorption properties, and the wave absorbing mechanism can be attributed to the dielectric loss, magnetic loss and the synergetic effect between RGO+Mn Fe 2O4, RGO-PV DF and MnFe2 O4+PvDF.
Journal ArticleDOI
Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer
Jonghoon Kim,Hye Rim Cho,Hye Rim Cho,Hyejin Jeon,Hyejin Jeon,Dokyoon Kim,Changyeong Song,Nohyun Lee,Seung Hong Choi,Seung Hong Choi,Taeghwan Hyeon +10 more
TL;DR: Biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) are designed to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT and demonstrating great potential of MFMSNs for theranostic agents in cancer therapy.
Journal ArticleDOI
Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering
Hong Zhao,Ruihua Ding,Xin Zhao,Yiwei Li,Liangliang Qu,Hao Pei,Lara Yildirimer,Zhengwei Wu,Weixia Zhang +8 more
TL;DR: The biomedical applications of graphene-based nanomaterials (GBNs) are discussed, including drug and/or gene delivery, bioimaging, and tissue engineering, and their unique properties related to their biomedical applications are discussed.
Journal ArticleDOI
A comprehensive review of graphene nanocomposites: research status and trends
TL;DR: A comprehensive review of the present trends in graphene research with an emphasis on graphene-based nanocomposites and their applications is provided in this article, which concludes with a discussion of the impact of graphene in composites and the future challenges to meeting industrial demands.
Journal ArticleDOI
Graphene-Based Smart Platforms for Combined Cancer Therapy
TL;DR: The recent advances of smart graphene platforms for combined therapy applications are presented, starting with the principle for the design of graphene‐based smart platforms in combined therapy Applications and current challenges and future prospects regarding this promising field are discussed.
References
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Journal ArticleDOI
The chemistry of graphene oxide
TL;DR: This review will be of value to synthetic chemists interested in this emerging field of materials science, as well as those investigating applications of graphene who would find a more thorough treatment of the chemistry of graphene oxide useful in understanding the scope and limitations of current approaches which utilize this material.
Journal ArticleDOI
Ultra-large-scale syntheses of monodisperse nanocrystals.
Jongnam Park,Kwangjin An,Yosun Hwang,Je-Geun Park,Han-Jin Noh,Jae Young Kim,Jae-Hoon Park,Nong-Moon Hwang,Taeghwan Hyeon +8 more
TL;DR: This work is able to synthesize as much as 40 g of monodisperse nanocrystals in a single reaction, without a size-sorting process, and the particle size could be controlled simply by varying the experimental conditions.
Journal ArticleDOI
Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Shouheng Sun,Hao Zeng,David B. Robinson,Simone Raoux,Philip M. Rice,Shan X. Wang,Guanxiong Li +6 more
TL;DR: As-synthesized iron oxide nanoparticles have a cubic spinel structure as characterized by HRTEM, SAED, and XRD and can be transformed into hydrophilic ones by adding bipolar surfactants, and aqueous nanoparticle dispersion is readily made.
Journal ArticleDOI
PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs
TL;DR: The results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.