Journal ArticleDOI
Synthesis of well-defined hydrogel networks using Click chemistry
Michael Malkoch,Robert Vestberg,Nalini Gupta,Laetitia Mespouille,Laetitia Mespouille,Philipe Dubois,Andrew F. Mason,James L. Hedrick,Qi Liao,Curtis W. Frank,Kevin Kingsbury,Craig J. Hawker +11 more
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TLDR
New PEG-based hydrogel materials have been synthesized by Click chemistry and shown to result in well-defined networks having significantly improved mechanical properties.About:
This article is published in Chemical Communications.The article was published on 2006-06-26. It has received 546 citations till now. The article focuses on the topics: Click chemistry & Self-healing hydrogels.read more
Citations
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Cu-catalyzed azide-alkyne cycloaddition.
TL;DR: The basis for the unique properties and rate enhancement for triazole formation under Cu(1) catalysis should be found in the high ∆G of the reaction in combination with the low character of polarity of the dipole of the noncatalyzed thermal reaction, which leads to a considerable activation barrier.
Journal ArticleDOI
Hydrogels in regenerative medicine
Brandon V. Slaughter,Shahana S. Khurshid,Omar Z. Fisher,Ali Khademhosseini,Nicholas A. Peppas +4 more
TL;DR: The properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed.
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Why are double network hydrogels so tough
TL;DR: In this article, double-network gels are characterized by a special network structure consisting of two types of polymer components with opposite physical natures: the minor component is abundantly crosslinked polyelectrolytes (rigid skeleton) and the major component comprises of poorly cross-linked neutral polymers (ductile substance).
Journal ArticleDOI
‘Click’ Chemistry in Polymer and Materials Science
TL;DR: The metal catalyzed azide/alkyne "click" reaction (a variation of the Huisgen 1,3-dipolar cycloaddition reaction between terminal acetylenes and azides) represents an important contribution towards this endeavor.
Journal ArticleDOI
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
TL;DR: This review focuses on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators.
References
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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Journal ArticleDOI
Temperature-sensitive aqueous microgels.
TL;DR: Although most of the work involves gels based on poly(N-isopropylacrylamide), other polymers are also considered and core-shell latex particles exhibiting temperature-sensitive properties are also described.
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Photopolymerizable hydrogels for tissue engineering applications.
Kytai T. Nguyen,Jennifer L. West +1 more
TL;DR: Advantages of photopolymerization of hydrogels are presented, the photoinitiators and materials in current use are described and the applications that have been investigated are summarized.
Book
Hydrogels in Medicine and Pharmacy
TL;DR: Hydrogels in medicine and pharmacy, Hydrogel-like properties, and their applications in pharmacy and medicine are investigated.