Journal ArticleDOI
Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base
Kenan Buldurun,Nevin Turan,Ercan Bursal,Asim Mantarcı,Fikret Türkan,Parham Taslimi,İlhami Gülçin +6 more
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TLDR
In this article, two different Schiff base Fe(II) and Co-II metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde.Abstract:
Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis, thermogravimetry–differential thermal analysis (TGA–DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with Ki values of 52.83 ± 11.52 and 63.34 ± 8.88, respectively.read more
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Antioxidants and antioxidant methods: an updated overview
TL;DR: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes as discussed by the authors, and many studies evaluating the antioxidant activity of various samples of research interest have been conducted.
Journal ArticleDOI
Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds - Determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibition properties.
İlhami Gülçin,Boris A. Trofimov,Ruya Kaya,Parham Taslimi,Lyubov N. Sobenina,Elena Yu. Schmidt,Olga V. Petrova,Svetlana F. Malysheva,Nina K. Gusarova,Vagif Farzaliyev,Afsun Sujayev,Saleh Alwasel,Claudiu T. Supuran +12 more
TL;DR: In this article, the synthesis of compounds of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds were evaluated against the human erythrocyte carbonic anhydrase I, and II isoenzymes, butyrylcholinesterase (BChE), and α-glycosidase enzymes.
Journal ArticleDOI
Iron (III) and zinc (II) monodentate Schiff base metal complexes: Synthesis, characterisation and biological activities
Bushra Naureen,G.A. Miana,Khadija Shahid,Mehmood Asghar,Samreen Tanveer,Aziza Sarwar,Aziza Sarwar +6 more
TL;DR: The above results suggest that both ligands and their metal complexes have the potential to be explored as active pharmaceutical agents, especially all zinc (II) complexes.
Journal ArticleDOI
Cobalt and ruthenium complexes with pyrimidine based schiff base: Synthesis, characterization, anticancer activities and electrochemotherapy efficiency
TL;DR: In this paper, a new Schiff base ligand and its two M(II) complexes [CoCl·L(H2O)2]·2H 2O, [RuCl(p-cymene)L] were synthesized and the structural features were confirmed from their micro analytical, IR, UV-Vis., 1H 13C NMR, TGA, X-ray diffraction analysis, mass spectral data and magnetic susceptibility measurements.
Journal ArticleDOI
Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves - phytochemical content by LC-MS/MS analysis
Leyla Polat Kose,Zeynebe Bingol,Ruya Kaya,Ahmet C. Gören,Hulya Akincioglu,Lokman Durmaz,Ekrem Köksal,Saleh Alwasel,İlhami Gülçin +8 more
TL;DR: In this article, the authors examined antioxidant capacity and anticholinergic properties of avocado (Folium perseae) leaves, extracted by water (WEFP) and ethy...
References
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Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Journal ArticleDOI
The Scherrer Formula for X-Ray Particle Size Determination
TL;DR: An exact derivation of the Scherrer equation is given for particles of spherical shape, values of the constant for half-value breadth and for integral breadth being obtained in this article, and various approximation methods which have been used are compared with the exact calculation.