Journal ArticleDOI
Synthesis, transport and fate of acetylcholinesterase in cultured chick embryo muscle cells
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TLDR
The intracellular transport pathway and metabolic requirements for secretion in cultured muscle cells are defined and form the basis for a comparison of the metabolism of membrane-bound and secreted glycoproteins from this cell type.About:
This article is published in Cell.The article was published on 1980-11-01. It has received 134 citations till now. The article focuses on the topics: Membrane glycoproteins & Cell membrane.read more
Citations
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Journal ArticleDOI
Molecular and cellular biology of cholinesterases
TL;DR: In this article, the authors propose a method to identify the root cause of a problem.Abbreviations: [2]... ].., [3]
Journal ArticleDOI
The Molecular Forms of Cholinesterase and Acetylcholinesterase in Vertebrates
J Massoulié,S Bon +1 more
TL;DR: The mechanism of cholinergic neurotransmission requires the rapid inac tivation of acetylcholine, which exists in all classes of vertebrates and is characterized in horse serum by Stedman et al (1932), who called it choli nesterase.
Journal ArticleDOI
Diffuse transmission by acetylcholine in the CNS
TL;DR: The notions of diffuse transmission and of an ambient level of ACh in the CNS could also be of clinical relevance, in accounting for the production and nature of certain cholinergic deficits and the efficacy of substitution therapies.
References
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Journal ArticleDOI
Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.
TL;DR: The methods were tested with samples from central and peripheral nervous tissues and purified enzymes and the values of choline acetyltransferase activity obtained in the presence of sodium cyanide or EDTA and synthetic acetyl-CoA were similar to those obtained with acetyl -CoA synthesized in situ.
Journal ArticleDOI
Control of acetylcholine receptors in skeletal muscle
TL;DR: It is proposed that the number and the distribution of ACh receptors in skeletal muscle are controlled by modulation of receptor metabolism and modulation of associations between receptor molecules or between receptors and other, as yet unidentified, elements in neuromuscular junctions and at extrajunctional sites where receptors are clustered.
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A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations
TL;DR: A rapid and simple radiometric assay for cholinesterase, suitable for multiple determinations, has been developed, highly reproducible, quite sensitive, and useful for applications in which multiple samples must be quickly assayed.
Journal ArticleDOI
Acetylcholine receptor turnover in membranes of developing muscle fibers.
TL;DR: It is concluded that acetylcholine receptors in the surface membranes of chick and rat myotubes developing in cell cultures have a half-life of 22-24 h and evidence suggest that receptors are incorporated into the surface membrane from a presynthesized set of receptors containing about 10% as many alpha-bungarotoxin binding sites as does the surface.
Journal ArticleDOI
Phorbol ester-induced morphological changes in transformed chick fibroblasts: Evidence for direct catalytic involvement of plasminogen activator
TL;DR: PA itself can catalytically alter cellular behavior in culture independent of plasminogen, until not its only known natural substrate.
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The Molecular Forms of Cholinesterase and Acetylcholinesterase in Vertebrates
J Massoulié,S Bon +1 more